CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Fisioterapia from Universidade Federal de São Carlos (1987), Master's at Anatomy from Universidade de São Paulo (1994) and PhD at Anatomy from Universidade de São Paulo (1999). Post-doc Department of Anatomy and Cell Biology of the University of Melbourne / Australia. She is Associate Professor of the Department of Anatomy / ICB / USP. She is Honorary Visiting Academic of Department of Anatomy and Cell Biology from the University of Melbourne. Member of the American Gastroenterological Association. She coordinates the Human Anatomy disciplines for the Physiotherapy and Medicine / FMUSP courses. The research is in the area of #8203;#8203;the Digestive System, in the enteric nervous system. Evidence indicates that intestinal ischemia / reperfusion and intestinal inflammation affect the enteric nervous system and enteric glia cells. The objective of the laboratory is to study immunohistochemical techniques, molecular biology and intestinal motility, the effects of intestinal inflammation and ischemia / reperfusion in the enteric nervous system and enteric glia cells, related to intestinal motility, intestinal microbiota, purinergic receptors, TNF-alpha receptors. and receptors for short chain fatty acids. Guides students of Scientific Initiation, Master, Master and Post-doctorate. e-mail: pcastel@usp.br (Source: Lattes Curriculum)
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Intestinal inflammation affects enteric neurons. Butyrate is a short-chain fatty acid produced by bacteria in the intestinal microbiota from the fermentation of dietary fibers. It binds to G protein-coupled fatty acid receptors, such as GPR41, GPR43 and GPR109, and contributes to the maintenance of the intestinal barrier, protection against pathogens and, as an anti-inflammatory. The pres…
5'-adenosine triphosphate (ATP) is known as a neurotransmitter and its receptors are the P2X1-7. The presence of P2X2, 3, 7 purinergic receptor in the enteric nervous system has been demonstrated. Ulcerative colitis and Crohn's disease present pathophysiological processes, necrosis of the gut and the enteric neurons and enteric glial cells. It has been demonstrated the participation of th…
Enteric glial cells are considered as a structural support for enteric neurons, but recent evidence suggests an interaction glia-neuron communication contributes to neuronal maintenance and that these changes (functional or morphological) cells may play a role in gastrointestinal disorders. Ischemia and reperfusion are severe clinical events with high mortality occurring in transplantatio…
(Only some records are available in English at this moment)
Ulcerative colitis (UC) compromises the enteric nervous system (ENS), affecting intestinal motility. The purinergic P2X7 receptor is involved in inflammatory and apoptotic pathways during UC. Female sex hormones, such as estrogen, can modulate these inflammatory responses, primarily through estrogen receptors ER¿ and ER¿. This study aims to investigate the effects of P2X7 receptor deficie…
The brain-gut axis is a bidirectional pathway of communication between the central and enteric nervous systems, so that disorders in the brain or gastrointestinal tract do not remain restricted to the site of origin. Several studies are based on the influence of the intestinal microbiota on neurodegenerative diseases. It is believed that, in situations of dysbiosis, bacterial metabolites …
Inflammatory Bowel Diseases affect the neurons of the Enteric Nervous System (ENS). Butyrate is a short-chain fatty acid (SCFA) produced by bacteria of the intestinal microbiota, from the fermentation of dietary fibers. It binds to G protein-coupled fatty acid receptors such as GPR41, GPR43 and GPR109A and triggers anti-inflammatory effects, improves intestinal barrier and protection agai…
(Only some records are available in English at this moment)
The short-chain fatty acid receptor coupled to the G protein contributes to the maintenance of the intestinal barrier, and protection against pathogens and inflammation. The presence of short-chain fatty acid receptors GPR41 in the enteric nervous system has been observed. Intestinal inflammation affects the enteric nervous system. The literature demonstrates that butyrate has been promis…
The Enteric Nervous System (ENS) is constituted by myenteric and submucosal plexus, whose purpose is to maintain of gastrointestinal activities. It has been observed that there is a reduction of myenteric neurons following ischemia and reperfusion. ATP is considered a neurotransmitter, which P2X1 to P2X7 are receptors and have been described in the enteric neurons. The pannexins are a fam…
In the digestive tract ischemia/reperfusion causes morphological changes in enteric neurons (LINDESTRÖM and EKBLAD, 2004; RIVERA et al., 2009; PAULINO et al, 2011), and in diseases such as acute mesenteric ischemia and Crohn's disease presenting as pathophysiological necrosis of the intestine. This project aims to study in ileum enteric nervous system of rats subjected to ischemia/reperfu…
(Only some records are available in English at this moment)
The enteric nervous system is composed of the myenteric and submucosal plexuses, which control motility, the transport of fluids from the mucosa, and local blood flow. These plexuses are formed by neurons and glial cells. Intestinal ischemia/reperfusion (I/R-i) injury is a common, and devastating problem in hospitalized patients, and is associated with high morbidity and mortality in both…
Ischemia/reperfusion (I/R) damage to the intestine occurs following shock, sepsis, vascular surgery, strangulation ileus, embolism, intestinal obstruction, necrotising enterocolitis and small intestine transplantation (Wedel et al. 1998; Mallick et al. 2004). Ischemic events are also associated with inflammatory bowel disease, and may precede disease development (Thornton and Solomon 200…
The work we have done on the consequences of inflammation induced by TNBS in enteric neurons over the last few years, using electrophysiological methods and measures of second messenger activation, has demonstrated changes in specific classes of neurons (Nurgali et al. 2007; Poole et al. 2007). The fact that specific classes of neuron are affected probably influences the outcome of inflam…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 9 / 7 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 8 / 5 | Completed scholarships in Brazil |
| 5 / 4 | Completed scholarships abroad |
| 27 / 21 | All research grants and scholarships |
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