CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Maria Oliveira de Souza completed her doctorate in Physiological Sciences, concentration area Renal Physiology, from the University of São Paulo (1999) with a sandwich from the Albert Einstein College of Medicine -USA. She did her postdoctoral work at Johns Hopkins University-USA, working as a research fellow in the Division of Gastroenterology. She is currently Associate Professor 3 at the Department of Physiology and Biophysics at the Institute of Biomedical Sciences of the University of São Paulo, Coordinator of the Postgraduate Program in Sciences - Human Physiology and Vice-President of the Postgraduate Committee of the Institute of Biomedical Sciences at USP. She has experience in the area of #8203;#8203;Organ and System Physiology, with an emphasis on Renal Pathophysiology. His research group aims to understand the molecular and functional mechanisms involved in acute kidney failure and the progression of chronic kidney disease. In addition, it seeks to identify possible targets for the development of new therapies. She has experience in investigating factors associated with renal hemodynamics, glomerular injuries, tubular function and sodium transport proteins. (Source: Lattes Curriculum)
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The progression from acute kidney injury (AKI) to chronic kidney disease (CKD) is a reality for millions of people around the world. Even with the advancement of scientific investigations, there is still a lack of information about cell signaling pathways around this topic, especially relative to renal fibrosis. Some studies have highlighted the importance of matrix metalloproteinases (MM…
Chronic kidney diseases are still a leading cause of death worldwide. Thus, the need for new treatment approaches is urgent. Here, we aim to unravel new sensing mechanisms for organelles on renal and immune cells and how the external and internal perception of unbalance is involved in responses which triggers injury, influences repair, and promotes renal tissue fibrosis. We hypothesize th…
Crystalline nephropathy (CN) and renal ischemia followed by reperfusion (IR) induce acute kidney injury (AKI), but there are not enough data regarding treatment, tissue repair molecules or the progression of AKI to the chronic phase in both pathologies, and recurrence in the case of CN. Recent studies by our group evidenced an increase in the inflammatory and fibrotic profiles of the rena…
Acute Kidney Injury (AKI) is one of the most common causes for the progression of Chronic Kidney Disease (CKD) and consequent loss of renal function. However, the pathophysiological mechanisms associated with the transition from AKI to CKD under conditions of drug nephrotoxicity, Diabetes Mellitus or renal ischemia/reperfusion are poorly understood. Thus, the current proposal is composed …
Chronic kidney disease (CKD) is a public health problem characterized by high morbidity and mortality and with important social and economic impact on the health system. Acute kidney injury (AKI) secondary to the ischemia and reperfusion process is a common condition for the progression of CKD associated with increased renin-angiotensin system activity, inflammation, fibrosis and decrease…
(Only some records are available in English at this moment)
Acute kidney injury (AKI) induced by ischemia/reperfusion (IR) contributes to a high rate of morbidity and mortality in a wide range of injuries. In this condition, renal tubular cells suffer severe damage that can interfere with the body's homeostasis, including sodium and water balance, since lesions in the tubular epithelia prevent the proper function of sodium transporters such as the…
The progression of acute kidney injury (AKI) to chronic kidney disease (CKD) is a reality for millionsof people around the world. Despite the advances in scientific research, there is still a lack of information onthe cellular signaling pathways involved in this issue, especially in relation to renal fibrosis and tubular injury.Some studies have highlighted the importance of matrix metall…
Cisplatin is an antineoplastic molecule extensively used in the treatment of breast, cervical, esophageal, bladder, lung and testicular cancers, and a potent nephrotoxic agent responsible for the induction of acute kidney injury (AKI), with a focus on tubular injury. To date, little is known about the effect of cisplatin on the cellular mechanisms responsible for tubular injuries. On the …
(Only some records are available in English at this moment)
Among the various factors that contribute to the evolution of CKD, focal segmental glomerulosclerosis (FSGS) gains relevance, while the glomerular fibrotic lesion corroborates the loss of renal function. Studies demonstrate that the transcription factor Early Growth Response (Egr-1) and mitogen-activated protein kinases (MAPK) are associated with kidney diseases, including glomerulosclero…
The apelinergic system plays an essential role in cardiovascular physiology and fluid and electrolyte balance has been the subject of recent studies involving the kidneys. Apelins are endogenous peptides that interact with the G protein coupled APJ receptor and exert effects on glomerular hemodynamics as well as tubular function. Recently, the activation of the apelinergic system has been…
The renal lithiasis or urinary stones is a frequent pathology in clinical practice with serious consequences depending on the duration and the frequency of recurrence of the insult. Although your clinical importance, little is known about the cellular mechanisms associated with acute kidney injury (AKI) due to the presence of kidney stones; the progression from the acute stage to chronic …
(Only some records are available in English at this moment)
Acute kidney injury (AKI) is a major determinant of mortality and morbidity in hospitalized patients. Understanding the pathophysiology of AKI is essential for the development of therapy. Furthermore, AKI itself can lead to de novo chronic kidney disease (CKD) and progression towards end stage kidney disease. This application proposes to study the role of Tamm-Horsfall protein (THP) in re…
| 2 / 2 | Ongoing grants |
| 9 / 5 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 18 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 35 / 21 | All research grants and scholarships |
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