Antonio Carlos Cicogna

• Abstract

  Obesity is a chronic metabolic disease characterized by abnormal or excessive accumulation of fat in relation to lean tissue mass. It is considered a global epidemic caused by multiple factors, being primarily responsible for this pathology sedentary lifestyle combined with excessive food intake. Comorbidities such as, cancer, insulin resistance, type 2 diabetes mellitus, dyslipidemia and…

  Myocardial proteome of obese rats by Western diet with cardiac dysfunction, AP.R

• Abstract

  The incidence and prevalence of obesity worldwide has increased progressively in recent decades and is now considered a global epidemic and a major public health problem. Several experimental studies have shown that obesity causes myocardial dysfunction in rats. While it is clear that a variety of damage in cardiac performance occurs with obesity, the mechanisms responsible for these chan…

  Participation of adrenergic system in the myocardial dysfunction induced by obesity, AP.R

• Abstract

  Under pressure overload conditions, the heart undergoes an adaptative process of cardiac remodelation (CR). Among the forms that it presents itself, ventricular hypertrophy stands out. It determines, initially, an improvement in sytolic function, searching cardiac stability maintenance. However, in the longterm picture, CR represents a risk factor for ventricular dysfunction and heart fai…

  Evaluation of the SERCA2a role in left ventricle diastolic dysfunction in rats submitted to supravalvar aortic stenosis, AP.R

(Only some records are available in English at this moment)

• Abstract

  Obesity is a chronic metabolic disease characterized by abnormal or excessive accumulation of fat in relation to lean tissue mass. It is considered a global epidemic and its incidence and prevalence have progressive increase in recent decades. Its etiology results from the interaction between genetic, environmental, behavioral and physiological factors, being excessive food intake combine…

  Evaluation of the moment in which obesity induced by western diet promotes cardiac remodeling in wistar rats, BP.IC

• Abstract

  Several experimental models have been proposed to study cardiac remodeling (CR); among them, the induction to supravalvar aortic stenosis (SAS). Physiopathological mechanisms responsible for cardiac function depression in this model of study are not well defined, however, there is relation to changes in intracellular calcium transient and their regulatory proteins. Calcium transient is on…

  Participation of calcium transient and their regulatory proteins in cardiac function improvements in rats with supravalvar aortic stenosis and ventricular dysfunction submitted to exercise training, BP.DR

• Abstract

  Obesity is a chronic metabolic disease characterized by abnormal or excessive accumulation of fat in relation to lean tissue mass. It is considered a global epidemic caused by multiple factors, being primarily responsible for this pathology sedentary lifestyle combined with excessive food intake. Comorbidities such as, cancer, insulin resistance, type 2 diabetes mellitus, dyslipidemia and…

  Myocardial proteome of obese rats by Western diet with cardiac dysfunction, BP.DR

(Only some records are available in English at this moment)

• Abstract

  The obesity has been identified as a nutritional disorder related to high incidence of comorbidities, including cardiovascular diseases. Abundant evidence shows that excess of adipose tissue is associated with deleterious effect in the heart function in both humans and animal models, however the mechanisms related to damage cardiovascular are not fully elucidated, thus studies in this dir…

  MYOCARDIAL PROTEOME OF WESTERN DIET-INDUCED OBESE RATS WITH CARDIAC DYSFUNCTION: A LABEL-FREE SHOTGUN PROTEOMIC APPROACH, BE.EP.DR

• Abstract

  This project aims to study: 1) the effects of hyperlipidic dietary treatment on energy metabolism and cardiac function after the establishment of ventricular hypertrophy accompanied by diastolic dysfunction in rats with supravalvar aortic stenosis; and 2) to investigate whether enhanced endogenous lipid metabolism exerts a cardioprotective effect during chronic lipid overload, by reducing…

  Influence of high fat diets on lipid energy metabolism and cardiac dysfunction in rodents during chronic cardiac stress, BE.EP.DR

• Abstract

  Recent evidences suggest that non-alcoholic fatty liver disease is an important risk factor for cardiovascular disease. However, it is still unclear if the cardiovascular risk is more present in pure steatosis or necro-inflammation characteristic of non-alcoholic steatohepatitis. The objective of this study will be characterizing the non-alcoholic fatty liver disease in a chronic overload…

  Characterization of nonalcoholic fatty liver disease in a chronic nutritional overload condition, BE.EP.PD

(Only some records are available in English at this moment)