graduate at Farmacia from Universidade do Sagrado Coração (1998), master's at General Biology from Universidade Estadual de Campinas (2000) and ph.d. at General Biology from Universidade Estadual de Campinas (2002). Has experience in Morphology, focusing on Human Anatomy, acting on the following subjects: neuromuscular junction, mdx mice, acetylcholine receptors, mdx and regenerated muscle fibers. (Source: Lattes Curriculum)
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The administration of glucorticoids is currently the standard pharmacological treatment prescribed for patients with Duchenne muscular disease (DMD). Due to its side effects, the search for alternative therapies that minimize the evolution of the disease and improve the quality of life of dystrophic patients is necessary. In this context, we hypothesized that the combination of photobiomo…
Oxidative stress has been considered a major factor in the physiopathogenesis of muscular dystrophies, especially in Duchenne muscular dystrophy (DMD). Despite the high concentration of antioxidant enzymes, such as superoxide dismutase, catalase and glutathione, observed in dystrophic patients and mdx mice, the antioxidant system can not restore the body's balance. In view of the above, w…
The objective of this study is to analyze the effects "in vivo and in vitro" the association of inflammatory Diacerhein with antioxidant Vitamin E on the muscle fibers of dystrophic mdx mice. In the studies "in vivo", mdx mice with 14 days of postnatal life will be divided into 4 groups: (1) treated with saline, (2) treated with the combination of Diacerhein and Vitamin E, (3) treated wit…
(Only some records are available in English at this moment)
Currently the most widely used treatment in patients with Duchenne muscular dystrophy (DMD) is the administration of corticosteroids, but prolonged use produces several serious side effects. Thus, it is critical to search for alternative therapies that minimize disease progression and improve quality of life of dystrophic patients with fewer side effects than corticosteroids. Since oxidat…
Intense inflammatory process and oxidative stress are factors that contribute to the physiopathogenesis of dystrophic muscle fibers. Among the mechanisms involved in the inflammatory response in Duchenne muscular dystrophy (DMD) and mdx mice (experimental model of DMD), highlights the signaling pathway of NF-ºB factor whose the primary action via is the activation of cytokines pro-inflamm…
Intense inflammatory process and oxidative stress are two process that contribute to the pathophysiology of dystrophic muscle fibers. Among the mechanisms involved in the inflammatory response in Duchenne muscular dystrophy (DMD) and mdx mice (an experimental model of DMD), stands out the signaling pathway of the factor of NF-kB, whose main route of action is the activation of cytokines p…
(Only some records are available in English at this moment)
Currently, there is no cure for Duchenne muscular dystrophy (DMD). While pharmacological treatments such as corticosteroids are routinely administered to control inflammation, their use is limited due to side effects. Myogenic progenitors derived from pluripotent stem cells (PSCs) hold great promise for future DMD therapies. The directed differentiation of PSCs into myotubes facilitates i…
| 6 / 4 | Completed research grants |
| 9 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 16 / 11 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID