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Luis Eduardo Soares Netto

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Universidade de São Paulo (USP). Instituto de Biociências (IB)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

He attended the University of Sao Paulo (Bacharel Degree in Biology, 1987; Ph.D. in 1992, under the guidance of Dr. Ohara Augusto). Later (from December 1992 to May 1996), I was a NIH Postdoctoral Fellow in the Laboratory of Biochemistry National Heart, Lung and Blood Institute in collaboration with Dr. Stadtman, E.R. Currently he is full professor at the Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo. He is interested in studying the mechanisms by which cells defend themselves against the toxic effects of free radicals and related species, with emphasis on a class of proteins called peroxiredoxin, which includes thioredoxin peroxidases. Therefore, their lines of research are focused on the redox chemistry and biology of thiols such as thioredoxin, glutaredoxin, peroxiredoxin and glutathione. Saccharomyces cerevisiae has been used as a model organism. The antioxidant defense mechanisms of pathogenic bacteria are also studied especially those from the phytopathogen Xylella fastidiosa, but also from Chromobacterium violaceum and Pseudomonas aeruginosa. His group has characterized for the first time the role of a new class of antioxidant enzymes, called Ohr ("Organic hydroperoxide Resistance protein). Such investigations have gained prominence as a result of the human microbiota metagenomic projects. It is noteworthy that Ohr enzymes are abundant in bacteria that colonize the gastrointestinal tract (Molecular & Cellular Proteomics 11: 1-13, 2012). As animals and plants generate oxidants in an attempt to kill pathogens, Ohr may play a role in the pathogenicity of bacteria. In this context, his group also performs structural biology analyzes of antioxidant proteins, elucidating Ohr structure. So far, the coordinates of eight protein structures were deposited at the Protein Data Bank. He is a member of the steering committee of the CEPID Redoxoma (; editorial board of the Free Radical Biology and Medicine and academic editor of PLoS One (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (17)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

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CUSSIOL, JOSE R. R.; ALEGRIA, THIAGO G. P.; SZWEDA, LUKE I.; NETTO, LUIS E. S.. Ohr (Organic Hydroperoxide Resistance Protein) Possesses a Previously Undescribed Activity, Lipoyl-dependent Peroxidase. Journal of Biological Chemistry, v. 285, n. 29, p. 21943-21950, . Web of Science Citations: 35. (07/58147-6)

DA SILVA NETO, JOSE F.; NEGRETTO, CAROLINE C.; NETTO, LUIS E. S.. Analysis of the Organic Hydroperoxide Response of Chromobacterium violaceum Reveals That OhrR Is a Cys-Based Redox Sensor Regulated by Thioredoxin. PLoS One, v. 7, n. 10, . Web of Science Citations: 17. (07/58147-6, 08/57721-3)

MEIRELES, DIOGO DE ABREU; PIRES ALEGRIA, THIAGO GERONIMO; ALVES, SIMONE VIDIGAL; ROCHA ARANTES, CARLA RANI; SOARES NETTO, LUIS EDUARDO. A 14.7 kDa Protein from Francisella tularensis subsp novicida (Named FTN_1133), Involved in the Response to Oxidative Stress Induced by Organic Peroxides, Is Not Endowed with Thiol-Dependent Peroxidase Activity. PLoS One, v. 9, n. 6, . Web of Science Citations: 5. (12/21722-1, 13/07937-8, 07/58147-6)

MALVEZZI, ALBERTO; HIGA, PATRICIA M.; AMARAL, ANTONIA T. -DO; SILVA, GUSTAVO M.; GOZZO, FABIO C.; FERRO, EMER S.; CASTRO, LEANDRO M.; DE REZENDE, LEANDRO; MONTEIRO, GISELE; DEMASI, MARILENE. The Cysteine-Rich Protein Thimet Oligopeptidase as a Model of the Structural Requirements for S-glutathiolation and Oxidative Oligomerization. PLoS One, v. 7, n. 6, . Web of Science Citations: 8. (07/58147-6, 08/06731-9)

SOARES NETTO, L. E.; MEDRANO, F. J.; RIBEIRO, J. A.; BARBOSA, G.; ALVES, S. V.; CUSSIOL, J. R. R.; GUIMARÃES, B. G.; OLIVEIRA, M. A. DE. Crystallization and preliminary X-ray diffraction analysis of an oxidized state of Ohr from Xylella fastidiosa. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, v. 60, n. 2, p. 337-339, .

TAIRUM, CARLOS A.; DE OLIVEIRA, MARCOS A.; HORTA, BRUNO B.; ZARA, FERNANDO J.; NETTO, LUIS E. S.. Disulfide Biochemistry in 2-Cys Peroxiredoxin: Requirement of Glu50 and Arg146 for the Reduction of Yeast Tsa1 by Thioredoxin. Journal of Molecular Biology, v. 424, n. 1-2, p. 28-41, . Web of Science Citations: 23. (07/58147-6, 08/57721-3)

DE OLIVEIRA, MARCOS ANTONIO; TAIRUM, CARLOS A.; SOARES NETTO, LUIS EDUARDO; PIRES DE OLIVEIRA, ANA LAURA; ALEIXO-SILVA, ROGERIO LUIS; MONTANHERO CABRERA, VITORIA ISABELA; BREYER, CARLOS A.; DOS SANTOS, MELINA CARDOSO. Relevance of peroxiredoxins in pathogenic microorganisms. Applied Microbiology and Biotechnology, v. 105, n. 14-15, . Web of Science Citations: 0. (16/15849-0, 20/00845-4, 19/04054-4, 17/19942-7, 11/13500-6, 13/07937-8, 17/06263-4, 20/02868-1)

SANTOS, CARLA SANTANA; BANNITZ-FERNANDES, RENATA; LIMA, ALEX S.; TAIRUM, CARLOS A.; MALAVAZI, IRAN; NETTO, LUIS E. S.; BERTOTTI, MAURO. Monitoring H2O2 inside Aspergillus fumigatus with an Integrated Microelectrode: The Role of Peroxiredoxin Protein Prx1. Analytical Chemistry, v. 90, n. 4, p. 2587-2593, . Web of Science Citations: 3. (15/20776-9, 13/14955-2, 15/02095-4, 14/22396-6)

PICCIRILLO, ERIKA; ALEGRIA, THIAGO G. P.; DISCOLA, KAREN F.; CUSSIOL, JOSE A. R. R.; DOMINGOS, RENATO M.; DE OLIVEIRA, MARCOS A.; DE REZENDE, LEANDRO; NETTO, LUIS E. S.; AMARAL, ANTONIA T-DO. Structural insights on the efficient catalysis of hydroperoxide reduction by Ohr: Crystallographic and molecular dynamics approaches. PLoS One, v. 13, n. 5, . Web of Science Citations: 2. (13/07937-8, 08/07971-3, 14/01614-5, 05/50056-6, 12/06633-2, 16/12392-9)

GOMES, FERNANDO; PALMA, FLAVIO ROMERO; BARROS, MARIO H.; TSUCHIDA, EDUARDO T.; TURANO, HELENA G.; ALEGRIA, THIAGO G. P.; DEMASI, MARILENE; NETTO, LUIS E. S.. Proteolytic cleavage by the inner membrane peptidase (IMP) complex or Oct1 peptidase controls the localization of the yeast peroxiredoxin Prx1 to distinct mitochondrial compartments. Journal of Biological Chemistry, v. 292, n. 41, p. 17011-17024, . Web of Science Citations: 4. (08/07971-3, 12/21722-1, 13/07937-8)

GOMES, FERNANDO; TURANO, HELENA; RAMOS, ANGELICA; NETTO, LUIS E. S.. Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, n. 173, . Web of Science Citations: 0. (17/09443-3, 13/07937-8, 17/23839-7)

CONDELES, ANDRE LUIS; GOMES, FERNANDO; DE OLIVEIRA, MARCOS ANTONIO; SOARES NETTO, LUIS EDUARDO; TOLEDO JUNIOR, JOSE CARLOS. Thiol Peroxidases as Major Regulators of Intracellular Levels of Peroxynitrite in Live Saccharomyces cerevisiae Cells. ANTIOXIDANTS, v. 9, n. 5, . Web of Science Citations: 0. (13/07937-8, 17/09443-3)

BANNITZ-FERNANDES, RENATA; ALEIXO-SILVA, ROGERIO; SILVA, JOAO PAULO; DODIA, CHANDRA; VAZQUEZ-MEDINA, JOSE PABLO; TAO, JIAN-QIN; FISHER, ARON; NETTO, LUIS. Non-Mammalian Prdx6 Enzymes (Proteins with 1-Cys Prdx Mechanism) Display PLA(2) Activity Similar to the Human Orthologue. ANTIOXIDANTS, v. 8, n. 3, . Web of Science Citations: 1. (16/12248-5, 13/07937-8)

MEIRELES, A.; DOMINGOS, R. M.; GAIARSA, J. W.; RAGNONI, E. G.; BANNITZ-FERNANDES, R.; DA SILVA NETO, J. F.; DE SOUZA, R. F.; NETTO, L. E. S.. Functional and evolutionary characterization of Ohr proteins in eukaryotes reveals many active homologs among pathogenic fungi. REDOX BIOLOGY, v. 12, p. 600-609, . Web of Science Citations: 5. (12/21722-1, 13/07937-8)

PREVIATO-MELLO, MARISTELA; MEIRELES, DIOGO DE ABREU; SOARES NETTO, LUIS EDUARDO; DA SILVA NETO, JOSE FREIRE. Global Transcriptional Response to Organic Hydroperoxide and the Role of OhrR in the Control of Virulence Traits in Chromobacterium violaceum. Infection and Immunity, v. 85, n. 8, . Web of Science Citations: 7. (12/20435-9, 12/21722-1, 13/25745-9)

SILVA, GUSTAVO M.; NETTO, LUIS E. S.; SIMOES, VANESSA; SANTOS, LUIZ F. A.; GOZZO, FABIO C.; DEMASI, MARCOS A. A.; OLIVEIRA, CRISTIANO L. P.; BICEV, RENATA N.; KLITZKE, CLECIO F.; SOGAYAR, MARI C.; et al. Redox Control of 20S Proteasome Gating. Antioxidants & Redox Signaling, v. 16, n. 11, p. 1183-1194, . Web of Science Citations: 47. (07/58147-6, 08/06731-9)

OLIVEIRA, MARCOS A.; DISCOLA, KAREN F.; ALVES, SIMONE V.; MEDRANO, FRANCISCO J.; GUIMARAES, BEATRIZ G.; NETTO, LUIS E. S.. Insights into the Specificity of Thioredoxin Reductase-Thioredoxin Interactions. A Structural and Functional Investigation of the Yeast Thioredoxin System. BIOCHEMISTRY, v. 49, n. 15, p. 3317-3326, . Web of Science Citations: 35. (07/58147-6)

ALEGRIA, THIAGO G. P.; MEIRELES, DIOGO A.; CUSSIOL, JOSE R. R.; HUGO, MARTIN; TRUJILLO, MADIA; DE OLIVEIRA, MARCOS ANTONIO; MIYAMOTO, SAYURI; QUEIROZ, RAPHAEL F.; VALADARES, NAPOLEAO FONSECA; GARRATT, RICHARD C.; et al. Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite. Proceedings of the National Academy of Sciences of the United States of America, v. 114, n. 2, p. E132-E141, . Web of Science Citations: 21. (08/07971-3, 12/21722-1, 13/07937-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PIMENTA, Marcela Valente. Investigação de facetas pró e antioxidantes de flavoproteínas de Xylella fastidiosa. Dissertação (Mestrado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (09/06833-9

ANSCHAU, Valesca. Caracaterização cinética da redução das 1-Cys Peroxirredoxinas por ascorbato. Tese (Doutorado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (12/00629-3

DISCOLA, Karen Fulan. Caracterização estrutural e funcional das glutarredoxinas ditiolicas de Saccharomyces cerevisiae. Tese (Doutorado) -  Instituto de Biologia.  Universidade Estadual de Campinas (UNICAMP).  (04/11908-4

DEMASI, Ana Paula Dias. Estudo da função de tiorredoxina peroxidase citoplasmatica I em Saccharomyces cerevisiae. Tese (Doutorado) -  Instituto de Biologia.  Universidade Estadual de Campinas.  (99/06150-5

HORTA, Bruno Brasil. Caracterização funcional e estrutural de peroxidases dependentes de tiól da bactéria fitopatogênica Xylella fastidiosa. Tese (Doutorado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (04/14440-3

CUSSIOL, José Renato Rosa. Caracterização funcional de uma nova proteína antioxidante: Ohr (Organic Hydroperoxide Resistance Protein). Vias de redução e expressão em Xylella fastidiosa. Tese (Doutorado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (05/50056-6

ALEGRIA, Thiago Geronimo Pires. Caracterização cinética e busca de inibidores de Ohr (Organic Hydroperoxide Resistance protein) de Xylella fastidiosa.. Dissertação (Mestrado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (08/07971-3

REYDON, Aline Francoise de Camargo. Investigação das defesas contra oxidantes provenientes do peroxissomo em Saccharomyces cerevisiae. Dissertação (Mestrado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (09/06531-2

GOMES, Fernando. Caracterização funcional da peroxirredoxina mitocondrial (Prx1) na fisiologia redox de Saccharomyces cerevisiae. Tese (Doutorado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (13/04240-6

FARIA, Victor Genu. Ahp1 e Tsa1 de Saccharomyces cerevisiae: regulação gênica, caracterização bioquímica, estrutura e função das duas peroxirredoxinas mais abundantes de leveduras. Tese (Doutorado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (02/13125-1

NAKAMATSU, Eduardo Hiroshi. Caracterização funcional e estrutural do sistema Tiorredoxina mitocondrial de Saccharomyces cerevisiae. Tese (Doutorado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (07/06747-0

FERNANDES, Renata Bannitz. Caracterização bioquí­mica e estrutural de peroxirredoxinas de Aspergillus fumigatus, fungo patógeno oportunista humano. Tese (Doutorado) -  Instituto de Biociências.  Universidade de São Paulo (USP).  São Paulo.  (13/14955-2

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