CV Lattes
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Universidade de São Paulo (USP). Faculdade de Odontologia (FO) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Associate Professor in the Discipline of Periodontology at the School of Dentistry of the University of São Paulo (FOUSP) since 2010. She holds a DDS degree from UNESP (1997), with specialization in Periodontology (1999) and Implant Dentistry (2023), as well as a Masters (2002) and PhD (2005) in Periodontology from FOAr-UNESP. She completed a Sandwich Doctoral Internship (20032004) and a Postdoctoral Fellowship (20052007) at the Mucosal Inflammation Research Group, Faculty of Medicine, University of Calgary, Canada, where she deepened her expertise in the immunoinflammatory mechanisms of periodontal diseases.She earned the title of Livre-Docente from FOUSP (2021) and has served as a Master's and PhD advisor in the Graduate Program in Dental Sciences at USP (CAPES Score 6) since 2011. She has solid experience in the design, development, and coordination (technical, scientific, and administrative) of translational research focused on investigating the host immune response in periodontal and peri-implant diseases, with an emphasis on biomarkers, systemic interactions, and immunomodulatory therapies.Throughout her career, she has systematically invested in expanding and updating her competencies through specialization and professional development courses in people management (MBA USP/Esalq), higher education teaching and pedagogical innovation, good clinical practices, periodontal and peri-implant plastic surgeries, and sustainability in dentistry.She has been actively involved in leading university extension and educational initiatives aimed at the prevention of peri-implant diseases and the strengthening of Primary Oral Health Care. She has also served as a faculty member in the Periodontology Specialization Program at FUNDECTO/FOUSP since 2015. (Source: Lattes Curriculum)
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Recent efforts in periodontal treatment have focused on regenerative approaches based in cells. The membranes have gained full attention on the repair/ regeneration of periodontal defects due to their ability to allow osteoblastic proliferation and to support the mineralized matrix formation. The obtainment of the cell sheets through the detachment of the cell layer from the culture dish …
Protease activated receptor 1 (PAR1) activation by thrombin can play an important role on periodontal tissue homeostase and healing. A recent study from our group has shown an increased expression of PAR1 in gingival crevicular fluid cells of chronic periodontitis patients after periodontal treatment, and that PAR1 expression is associated with decreased levels of inflammatory biomarkers.…
(Only some records are available in English at this moment)
Periodontal disease is highly prevalent and has as a characteristic the reabsorption of the periodontal ligament, cementum and alveolar bone. The regeneration of damaged tissues and organs is considered the ideal outcome of a treatment and has been sought through biological solutions once that traditional methods used for the treatment of bone defects have presented limitations. In this w…
The regeneration of periodontal tissues lost through periodontal disease has been sought through biological solutions since the current therapeutic alternatives available are not completely predictable and satisfactory. Periodontal ligament stem cells (PDLSCs) are able to differentiate into cementoblasts/osteoblasts, adipocytes and collagen-forming cells, contributing to periodontal tissu…
Periodontitis is defined as a chronic inflammatory disease that results in the destruction of periodontal tissue support formed by cementum, alveolar bone and periodontal ligament. Such destruction is due to the persistent presence of specific microorganisms in periodontal tissues. Studies indicate that bacterial proteases have the ability to modulate the immune-inflammatory response of t…
(Only some records are available in English at this moment)
Maresins (macrophage mediators in resolving inflammation) are a family of specialized proresolving mediators of macrophage origin. These mediators are biosynthesized via initial lipoxygenation and molecular oxygen insertion at the carbon 14 position of docosahexaenoic acid (DHA) followed by epoxidation and oxygen incorporation at the carbon 7 position from a molecule of H2O. This research…
The association of Protease-activated receptor 2 (PAR2) and periodontitis was first suggested by in vitro studies which demonstrated that osteoblasts, oral epithelial cells and human gingival fibroblasts can express PAR2. Furthermore, it was observed that a selective agonist of PAR2 causes gingival granulocyte infiltration in rats and PAR2-deficient (PAR2-/-) mice show less inflammation r…
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