CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelors degree in Pharmacy-Biochemistry (School of Pharmaceutical Sciences, University of São PauloFCF-USP, 2005) and PhD in Drugs and Medicines (FCF-USP, 2009). Associate Professor in the Department of Pharmacy, FCF-USP. Brings over a decade of pharmaceutical industry RD experience, leading projects from bench to industrial scale-up and product launch. Completed a postdoctoral fellowship at Purdue University (Department of Industrial and Physical Pharmacy; Solid State Lab, Prof. Stephen R. Byrn) supported by a FAPESP overseas research scholarship (20162017). Works in Pharmaceutical Technology and Solid-State Chemistry applied to oral and inhalation dosage forms (polymorphism, cocrystals, amorphous solid dispersions, and nanostructured systems/nanocrystals), with a focus on enhancing solubility, modulating drug release, and accelerating proof-of-concept, including drug repurposing for cancer and neglected diseases. Recipient of the 2019 Excellence New Research Leadership Award from USP and the "João Florentino Meira de Vasconcellos" laurel in Pharmaceutical Innovation from the Brazilian Academy of Pharmaceutical Sciences. (Source: Lattes Curriculum)
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Pyoderma is a disease that causes lesions on the skin of dogs, due to the proliferation of Gram-positive bacteria of the genus Staphylococcus sp., Staphylococcus pseudintermedius being the main agent of the disease. This is one of the most common pathologies in the skin of dogs. The treatment consists of antimicrobials administration such as beta-lactams, fluoroquinolones, macrolides, amo…
High dosages, unspecific targeting, clinical variability, high cost of formulations, poor water solubility, toxicity of cosolvents are recurrent problems in the development of antitumor drug therapies. Nanocrystal and Amorphous solid dispersions (ASD) are outstanding solid-state technologies suitable to overcome those problems helping to accelerate preclinical and clinical development and…
Polymorphism, the ability of a substance to crystallize in more than one lattice arrangement, is currently a major concern for the pharmaceutical industry. Albeit the molecule does not change, different packing architectures can lead to significant differences in physicochemical properties that play a key role in the performance of medicines. Thus, in recent years there has been a signifi…
This study aims to apply Process Analytical Technology (PAT) tools to evaluate the Critical Quality Attributes (CQAs) of itraconazole extrudates, with an emphasis on dosage, content uniformity, and the degree of drug amorphization. The incorporation of PAT tools provides greater assurance in development, manufacturing processes, and ultimately for patient safety. Throughout the study, phy…
Oncological drugs often face challenges such low solubility and poor bioavailability, leading to higher required doses, increased systemic toxicity, and adverse effects. Axitinib, a potent tyrosine kinase inhibitor targeting VEGF receptors, shows promising potential for glioblastoma treatment due to its anti-angiogenic properties. However, its therapeutic performance in brain tumors is hi…
Pharmaceutical nanocrystals are crystalline drug particles at the nanometer scale that hold great potential in the pharmaceutical industry due to their ability to enhance the solubility and bioavailability of poorly soluble medications. This research project focuses on the production and characterization of axitinib nanocrystals, an antineoplastic drug used in the treatment of advanced re…
This study aims to investigate the solubility of oxi-chloro telluro anisole, a newly discovered compound with significant therapeutic potential but low water solubility. The low aqueous solubility of drugs is a major challenge for the pharmaceutical industry, as it directly impacts the bioavailability and efficacy of medications. In this context, the creation of amorphous solid dispersion…
The low water solubility issue of antimalarial drugs is a challenge that calls for an urgent improvement and development of new formulations because the limited bioavailability causes the need for high dosages, variability in clinical response, emergence of resistance and efficacy problems. Recent advances in knowledge of crystal engineering present the possibility to design and synthesiz…
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Glioblastoma remains one of the most aggressive and treatment-resistant brain tumors, largely due to the restrictive nature of the blood-brain barrier (BBB) and the limited bioavailability of systemic therapies. Axitinib, a potent VEGF receptor tyrosine kinase inhibitor, shows therapeutic potential for glioblastoma due to its anti-angiogenic properties. However, its clinical application i…
This project aims to optimize ternary formulations for Hot Melt Extrusion (HME) by systematically investigating the rheological impact and thermal properties of various polymers and plasticizers on drug solubility and processability. Recognizing HME as a critical solvent-free technique for enhancing the bioavailability of poorly soluble drugs through amorphous solid dispersions (ASDs), th…
Amorphous solid dispersions (ASDs) have proven to be an effective strategy to address the low solubility of many drugs, a common challenge in pharmaceutical development. This project proposes a comparative analysis between the extended Flory-Huggins (xFH) and PC-SAFT models for predicting miscibility and solubility in ASDs. The xFH model incorporates compositional dependence into the drug…
Structural inequivalence is a state-of-the-art molecular architecture (strategy) that allows increasing the number of components in a simple co-crystal from a binary precursor to a higher order cocrystal (HOC) levels by substituting a weakly bonded molecule in the crystallographic space by another molecule with higher bonding energy and directionality. Recent advances in crystal engineeri…
Polymorphism can cause quality deviations during the production of medicines and can influence their effectiveness. Therefore, an understanding of this phenomenon and its implications opens a wide field of possibilities to be explored in the pharmaceutical field, including the emergence of new paradigms and tools for the quality assurance of medicines. Small molecule tyrosine kinase inhib…