Degree in Pharmacy and Biochemistry from Universidade de São Paulo (2005) and Ph.D. in Sciences (Pharmaceutical Production and Control of Medicines) from Universidade de São Paulo (2009); Currently serving as an Associate Professor in the Department of Pharmacy at the School of Pharmaceutical Sciences, University of São Paulo, he brings with him over a decade of expertise in both research and drug development within distinguished pharmaceutical industries. His successful leadership spans various projects, guiding them from the early stages to their industrial-scale launch. Between 2016 and 2017, he undertook a postdoctoral research stint at Purdue University in West Lafayette, Indiana, USA, specifically at the Department of Industrial and Physical Pharmacy (College of Pharmacy, Prof. Stephen R. Byrn), supported by a foreign research scholarship program (FAPESP). Fueled by a passion for Pharmaceutical Technology, his research dives into advanced solid-state technologies, delving into polymorphism, co-crystals, amorphous solid dispersions, and nanostructured systems, including nanocrystals. Leveraging sophisticated techniques like thermal analysis and X-ray diffraction, his work focuses on designing oral and inhalation formulations. The overarching strategies aim to enhance solubility, reduce dosage, modulate release, and expedite proof of concept. His research extends to drug repositioning for cancer and neglected diseases, with the ultimate goal of contributing to the empowerment of new generations of formulation scientists in the advancements of pharmaceutical technology, addressing challenges related to drug delivery, solubility, and therapeutic efficacy. His accolades include the 2019 Excellence New Research Leadership Award from USP and the "João Florentino Meira de Vasconcellos" laurel in Pharmaceutical Innovation from the Brazilian Academy of Pharmaceutical Sciences. (Source: Lattes Curriculum)
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Pyoderma is a disease that causes lesions on the skin of dogs, due to the proliferation of Gram-positive bacteria of the genus Staphylococcus sp., Staphylococcus pseudintermedius being the main agent of the disease. This is one of the most common pathologies in the skin of dogs. The treatment consists of antimicrobials administration such as beta-lactams, fluoroquinolones, macrolides, amo…
High dosages, unspecific targeting, clinical variability, high cost of formulations, poor water solubility, toxicity of cosolvents are recurrent problems in the development of antitumor drug therapies. Nanocrystal and Amorphous solid dispersions (ASD) are outstanding solid-state technologies suitable to overcome those problems helping to accelerate preclinical and clinical development and…
Polymorphism, the ability of a substance to crystallize in more than one lattice arrangement, is currently a major concern for the pharmaceutical industry. Albeit the molecule does not change, different packing architectures can lead to significant differences in physicochemical properties that play a key role in the performance of medicines. Thus, in recent years there has been a signifi…
Pharmaceutical nanocrystals are crystalline drug particles at the nanometer scale that hold great potential in the pharmaceutical industry due to their ability to enhance the solubility and bioavailability of poorly soluble medications. This research project focuses on the production and characterization of axitinib nanocrystals, an antineoplastic drug used in the treatment of advanced re…
This study aims to investigate the solubility of oxi-chloro telluro anisole, a newly discovered compound with significant therapeutic potential but low water solubility. The low aqueous solubility of drugs is a major challenge for the pharmaceutical industry, as it directly impacts the bioavailability and efficacy of medications. In this context, the creation of amorphous solid dispersion…
The low water solubility issue of antimalarial drugs is a challenge that calls for an urgent improvement and development of new formulations because the limited bioavailability causes the need for high dosages, variability in clinical response, emergence of resistance and efficacy problems. Recent advances in knowledge of crystal engineering present the possibility to design and synthesiz…
The pharmaceutical industry widely uses amorphous formulations to improve the low oral bioavailability of many BCS (biopharmaceutical classification system) class II drugs. This project aims to study the local structure of amorphous solid dispersions of poorly soluble drugs, focusing specifically on the structural aspects that may help select polymers that ensure efficient amorphization a…
Niclosamide is an effective anthelmintic agent that in recent years has been repositioned for use in the treatment of tumors and viral infections. Its low solubility in water, however, may compromise its effective use and performance in preclinical and clinical trials. The present project aims to explore possible alternatives through the research and development of solid dispersions for t…
Structural inequivalence is a state-of-the-art molecular architecture (strategy) that allows increasing the number of components in a simple co-crystal from a binary precursor to a higher order cocrystal (HOC) levels by substituting a weakly bonded molecule in the crystallographic space by another molecule with higher bonding energy and directionality. Recent advances in crystal engineeri…
Polymorphism can cause quality deviations during the production of medicines and can influence their effectiveness. Therefore, an understanding of this phenomenon and its implications opens a wide field of possibilities to be explored in the pharmaceutical field, including the emergence of new paradigms and tools for the quality assurance of medicines. Small molecule tyrosine kinase inhib…
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 3 / 2 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 11 / 10 | All research grants and scholarships |
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CV Lattes
ORCID