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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Maternal immunization with ovalbumin or Dermatophagoides pteronyssinus has opposing effects on Fc gamma RIIb expression on offspring B cells

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Author(s):
de Lima Lira, Aline Aparecida [1] ; de Oliveira, Marilia Garcia [1] ; de Oliveira, Luana Mendona [1] ; da Silva Duarte, Alberto Jose [1] ; Sato, Maria Notomi [1] ; Victor, Jefferson Russo [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Med, Lab Dermatol & Immunodeficiencies, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY; v. 10, SEP 2 2014.
Web of Science Citations: 7
Abstract

Background: Over the last decade, our group has demonstrated that murine preconception immunization with allergens has a protective effect on allergy development in offspring. The murine model used in the present study allowed us to compare allergy induction by ovalbumin (OVA) and dust mite extract from Dermatophagoides pteronyssinus (Dp). Findings: Female mice were immunized with OVA or Dp. Pups from immunized and non-immune mothers were immunized at 3 days old (do) with the same antigen used for the maternal immunization. The offspring were analyzed at 20 do. Preconceptional immunization with OVA or Dp did not increase maternal IgE serum levels, although the immunizations induced an increase in allergen-specific IgG1 Ab levels. Offspring serum analyses revealed that maternal immunization with OVA suppressed IgE production only in offspring immunized with OVA. Both preconception immunization protocols inhibited cellular influx into the airways of immunized offspring compared with controls. Similar frequencies of offspring IgM + B cells were found in the OVA- and Dp-immunized groups compared with their respective control groups. Moreover, preconception immunization with OVA enhanced Fc gamma RIIb expression on OVA-immunized offspring B cells. In contrast, decreased Fc gamma RIIb expression was detected on Dp-immunized offspring B cells compared with cells from the offspring of non-immune mothers. Conclusions: Together, these results show that preconception OVA immunization and Dp immunization can inhibit allergy development but have opposite effects on Fc gamma RIIb expression on offspring B cells. (AU)

FAPESP's process: 10/13262-5 - Neonatal allergic response regulation mediated by maternal immunization with OVA: influence of FcgRIIb inhibitory receptors and regulatory T cells
Grantee:Maria Notomi Sato
Support Opportunities: Regular Research Grants