Kinetics of rabies antibodies as a strategy for canine active immunization

Author(s)

Babboni, Selene Daniela ^[1] ; da Costa, Heni Falcao ^[2] ; Alves Martorelli, Luzia de Fatima ^[3] ; de Arruda Geraldes Kataoka, Ana Paula ^[3] ; Victoria, Cassiano ^[1] ; Padovani, Carlos Roberto ^[4] ; Modolo, Jose Rafael ^[1]

Affiliation

^[1] Sao Paulo State Univ, Univ Estadual Paulista, UNESP, Sch Vet Med & Anim Husb, Dept Vet Hyg & Publ Hlth, Botucatu, SP - Brazil

^[2] Sao Paulo State Univ, Univ Estadual Paulista, UNESP, Sch Vet Med, Dept Anim Hlth & Prod, Aracatuba, SP - Brazil

^[3] Ctr Control Zoonosis Sao Paulo City, Lab Zoonoses & Vector Borne Dis, Sao Paulo - Brazil

^[4] Sao Paulo State Univ, Univ Estadual Paulista, UNESP, Dept Biostat, Botucatu Biosci Inst, Botucatu, SP - Brazil

• Document type: Journal article
• Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 20, AUG 26 2014.
• Web of Science Citations: 4

Abstract

Background Rabies, a zoonosis found throughout the globe, is caused by a virus of theLyssavirus genus. The disease is transmitted to humans through the inoculation of the virus present in the saliva of infected mammals. Since its prognosis is usually fatal for humans, nationwide public campaigns to vaccinate dogs and cats against rabies aim to break the epidemiological link between the virus and its reservoirs in Brazil.Findings During 12 months we evaluated the active immunity of dogs first vaccinated (booster shot at 30 days after first vaccination) against rabies using the Fuenzalida-Palácios modified vaccine in the urban area of Botucatu city, São Pauto state, Brazil. Of the analyzed dogs, 54.7% maintained protective titers (≥0.5 IU/mL) for 360 days after the first vaccination whereas 51.5% during all the study period.Conclusions The present results suggest a new vaccination schedule for dogs that have never been vaccinated. In addition to the first dose of vaccine, two others are recommended: the second at 30 days after the first and the third dose at 180 days after the first for the maintenance of protective titers during 12 months. (AU)

• FAPESP's process: 09/09098-8 - Evaluation of active immunity of primary vaccinated dog (Fuenzalida & Palacios) in the range of vaccination campaigns against rabies in the city of Botucatu/SP
• Grantee: José Rafael Módolo
• Support Opportunities: Regular Research Grants