Design and Application of a Low-Temperature Continuous Flow Chemistry Platform

Author(s)

Newby, James A. ^[1] ; Blaylock, D. Wayne ^[2] ; Witt, Paul M. ^[2] ; Pastre, Julio C. ^[1] ; Zacharova, Marija K. ^[1] ; Ley, Steven V. ^[1] ; Browne, Duncan L. ^[1]

Affiliation

^[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW - England

^[2] Dow Chem Co USA, Midland, MI 48674 - USA

• Document type: Journal article
• Source: ORGANIC PROCESS RESEARCH & DEVELOPMENT; v. 18, n. 10, p. 1211-1220, OCT 2014.
• Web of Science Citations: 24

Abstract

A flow reactor platform technology applicable to a broad range of low temperature chemistry is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume. The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor. (AU)

• FAPESP's process: 12/05909-4 - Preparation of goniothalamin under flow reaction conditions
• Grantee: Júlio Cezar Pastre
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor