Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Modification of the brain proteome of Africanized honeybees (Apis mellifera) exposed to a subaEurolethal doses of the insecticide fipronil

Full text
Author(s):
Roat, T. C. [1] ; dos Santos-Pinto, J. R. A. [1] ; dos Santos, L. D. [2] ; Santos, K. S. [3] ; Malaspina, O. [1] ; Palma, M. S. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo State UNESP, Ctr Study Social Insects, Dept Biol, Inst Biosci Rio Claro, Rio Claro, SP - Brazil
[2] Univ Sao Paulo State UNESP, Ctr Study Venoms & Venomous Anim CEVAP, Botucatu, SP - Brazil
[3] Discipline Allergy & Immunol HC Incor FMUSP, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ECOTOXICOLOGY; v. 23, n. 9, p. 1659-1670, NOV 2014.
Web of Science Citations: 11
Abstract

Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized Apis mellifera workers, this study focused on the toxico-proteome profiling of the brain of newly emerged and aged honeybee workers that were exposed to a sub-lethal dose (10 pg fipronil per day. i.e. (1)/(100) of LD50/bee/day during 5 days) of the insecticide. Proteomic analysis identified 25 proteins that were differentially up-regulated or down-regulated when the fipronil-exposed and non-exposed groups were compared. These proteins are potentially related to pathogen susceptibility, neuronal chemical stress, neuronal protein misfolding, and occurrence of apoptosis, ischemia, visual impairment, damaged synapse formation, brain degeneration, memory and learning impairment. The exposure of honeybees to a very low dose of fipronil, even for a short period of time (5 days), was sufficient to cause a series of important neuroproteomic changes in the brains of honeybees. (AU)

FAPESP's process: 11/51684-1 - System biology as experimental strategy for discovery of novel natural products in the fauna of venomous arthropods from São Paulo State
Grantee:Mario Sergio Palma
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 12/13370-8 - How is the reaction of the Apis mellifera brain to a sublethal dose of thiamethoxam?
Grantee:Thaisa Cristina Roat
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 08/05018-7 - Toxicological effects of the insecticide fipronil in workers and queens of Apis mellifera (Hymenoptera: Apidae): neural activity and detoxification proteins
Grantee:Thaisa Cristina Roat
Support Opportunities: Scholarships in Brazil - Post-Doctoral