Heart rate variability and cardiorespiratory coupling in obstructive sleep apnea: elderly compared with young

Author(s):Show less -

Trimer, R. ^[1] ; Cabidu, R. ^[2] ; Sampaio, L. L. M. ^[3] ; Stirbulov, R. ^[4] ; Poiares, D. ^[5] ; Guizilini, S. ^[6] ; Bianchi, A. M. ^[2] ; Costa, F. S. M. ^[7] ; Mendes, R. G. ^[1] ; Delfino, Jr., A. ^[7] ; Arena, R. ^{[8, 9]} ; Borghi-Silva, A. ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Physiotherapy Dept, Cardiopulm Physiotherapy Lab, BR-13560 Sao Carlos, SP - Brazil

^[2] Politecn Milan, Div Dipartimento Elettron Informaz & Bioingn, Milan - Italy

^[3] Nove Julho Univ, Sao Paulo - Brazil

^[4] Uni Santa Casa Misericordia Sao Paulo, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Dept Psychobiol, Sleep Med & Biol Discipline, Sao Paulo - Brazil

^[6] Univ Fed Sao Paulo, Phys Therapy Sch, Dept Human Mot Sci, Sao Paulo - Brazil

^[7] Sleep Inst Sao Carlos, Sao Carlos - Brazil

^[8] Univ Illinois, Coll Appl Hlth Sci, Dept Phys Therapy, Chicago, IL - USA

^[9] Univ Illinois, Coll Appl Hlth Sci, Integrat Physiol Lab, Chicago, IL - USA

• Document type: Journal article
• Source: Sleep Medicine; v. 15, n. 11, p. 1324-1331, NOV 2014.
• Web of Science Citations: 5

Abstract

Introduction: Aging is known to be a major contributing factor to the increased risk of obstructive sleep apnea (OSA). With aging, breathing undergoes significant changes during sleep, increasing the prevalence of apnea events, which affects heart rate variability (HRV) and cardiorespiratory coupling (CRC). Objectives: To compare HRV and CRC during wakefulness and sleep between young and elderly patients with and without OSA; and to determine whether the presence of OSA in young and elderly patients has a different impact on HRV and CRC during sleep. Methods: One hundred subjects, 50 young (mean age, 27 +/- 9; 20 normal and 30 OSA) and 50 elderly (mean age, 65 +/- 7; 20 normal and 30 OSA), underwent polysomnography. Spectral, cross-spectrum, and HRV parameters were analyzed during wakefulness and sleep. Results: The spectral analysis indicated that age affected HRV, with higher values of low frequency (P < 0.05) in elderly subjects during wakefulness and an interaction between the presence of OSA and age. OSA influenced HRV during sleep with lower LF/HF ratios during stage 2 (S2) and rapid eye movement (REM) sleep (P < 0.05), with an interaction between the presence of OSA and age in REM sleep. Elderly patients had significantly lower percent tachogram power coherent with respiration (%TPCR) during wakefulness (P < 0.05), and OSA led to lower %TPCR during S2. Conclusions: Age and OSA have an unfavorable impact on HRV, with reduced autonomic modulation during wakefulness, S2, and REM sleep. Age affects CRC during wakefulness and the presence of OSA affects CRC during sleep. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 09/01842-0 - Analysis of central and peripheral muscle metabolism and adjustments on dynamic versus resistance exercise in coronary arterial disease patients: effects of resistance physical training program based on anaerobic threshold by different methodologies
• Grantee: Audrey Borghi Silva
• Support Opportunities: Research Grants - Young Investigators Grants