| Full text | |
| Author(s): |
de Melo Burger, Marcela C.
[1]
;
Fernandes, Joao Batista
[1]
;
das Gracas Fernandes da Silva, Maria F.
[1]
;
Escalante, Aster
[2]
;
Prudhomme, Jacques
[2]
;
Le Roch, Karine G.
[2]
;
Izidoro, Mario A.
[3]
;
Vieira, Paulo C.
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 - USA
[3] Univ Fed Sao Paulo, BR-04039002 Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 77, n. 11, p. 2418-2422, NOV 2014. |
| Web of Science Citations: | 6 |
| Abstract | |
Metrodorea stipularis stem extracts were studied in the search for possible antichagastic, antimalarial, and antitumoral compounds using cruzain from Trypanosoma cruzi, Plasmodium falciparum, and cathepsins B and L, as molecular targets, respectively. Dihydrochalcones 1, 2, 3, and 4 showed significant inhibitory activity against all the targets. Compounds 1-4 displayed IC50 values ranging from 7.7 to 21.6 mu M against cruzain; dihydrochalcones 2 and 4 inhibited the growth of three different strains of P. falciparum in low micromolar concentrations; and against cathepsins B and L these compounds presented good inhibitory activity with IC50 values ranging from 1.0 to 14.9 mu M. The dihydrochalcones showed good selectivity in their inhibitory activities against the cysteine proteases. (AU) | |
| FAPESP's process: | 10/00496-8 - Study of Medicinal Plants for the Treatment of Parasitic Diseases Using Enzymes as Molecular Targets |
| Grantee: | Marcela Carmen de Melo Burger |
| Support Opportunities: | Scholarships in Brazil - Doctorate |