| Full text | |
| Author(s): |
Buena, Cecilia Zorzi
[1]
;
Antunes Dias, Ana Maria
[2]
;
Cipriano de Sousa, Herminio Jose
[2]
;
Medeiros Braga, Mara Elga
[2]
;
Moraes, Angela Maria
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Campinas UNICAMP, Sch Chem Engn, Dept Engn Mat & Bioproc, BR-13083852 Campinas, SP - Brazil
[2] Univ Coimbra, FCTUC, Dept Chem Engn, CIEPQPF, P-3030790 Coimbra - Portugal
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Materials Science & Engineering C-Materials for Biological Applications; v. 44, p. 117-125, NOV 1 2014. |
| Web of Science Citations: | 20 |
| Abstract | |
This work addresses the development and characterization of porous chitosan-alginate based polyelectrolyte complexes, obtained by using two different proportions of the biocompatible surfactant Pluronic F68. These biomaterials are proposed for applications as biodegradable and biocompatible wound dressing and/or scaffolds. The results indicate that thickness, roughness, porosity and liquid uptake of the membranes increase with the amount of surfactant used, while their mechanical properties and stability in aqueous media decrease. Other important properties such as color and surface hydrophilicity (water contact angle) are not significantly altered or did not present a clear tendency of variation with the increase of the amount of surfactant added to the polyelectrolyte complexes, such as real density, average pore diameter, total pore volume and surface area. The prepared biomaterials were not cytotoxic to L929 cells. In conclusion, it is possible to tune the physicochemical properties of chitosan-alginate polyelectrolyte complexes, through the variation of the proportion of surfactant (Pluronic F68) added to the mixture, so as to enable the desired application of these biomaterials. (C) 2014 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 09/17755-9 - Porous chitosan-alginate membranes containing polyhexamethylene biguanide as a novel wound dressing |
| Grantee: | Cecilia Zorzi Bueno |
| Support Opportunities: | Scholarships in Brazil - Doctorate |