Luteal changes after treatment with sub-luteolytic doses of prostaglandin (cloprostenol sodium) in cattle

Author(s):Show less -

Trevisol, Eduardo ^[1] ; Ferreira, Jair Camargo ^[1] ; Ackermann, Camila Louise ^[1] ; Destro, Flavia Caroline ^[1] ; Marques Filho, Wolff Camargo ^[1] ; Carmagos, Aline Souza ^[1] ; Biehl, Marcos Vinicius ^[2] ; do Amaral, Jackson Barros ^[3] ; de Figueiredo Pantoja, Jose Carlos ^[4] ; Sartori, Roberto ^[2] ; Pinheiro Ferreira, Joao Carlos ^[1]

Affiliation

^[1] Univ Estadual Paulista FMVZ, Sch Vet Med & Anim Sci, Dept Anim Reprod & Vet Radiol, Botucatu, SP - Brazil

^[2] Univ Sao Paulo, ESALQ, Dept Anim Sci, Piracicaba, SP - Brazil

^[3] SAA, Inst Anim Sci, Nova Odessa, SP - Brazil

^[4] Univ Estadual Paulista FMVZ, Sch Vet Med & Anim Sci, Dept Vet Hyg & Publ Hlth, Botucatu, SP - Brazil

• Document type: Journal article
• Source: Animal Reproduction Science; v. 153, p. 8-12, FEB 2015.
• Web of Science Citations: 8

Abstract

This study characterizes the physiological and morphological changes related to partial luteolysis in bovine corpus luteum (CL) after challenges with sub-doses of cloprostenol sodium on Day 6 (D6) of the estrous cycle. Cows (n =12/treatment) were treated as follows: Control (2 mL, saline, i.m.); 2XPGF (two treatments i.m. 500 mu g of cloprostenol sodium 2 h apart) and 1/6PGF (83.3 mu g of cloprostenol sodium, i.m., once). Plasma progesterone (P4) concentration, CL volume and blood flow were measured immediately before the treatments, then every 8 h (h) for 48 h. In the Control, P4 concentrations were higher at 48 h than at Oh. P4 decreased 8 h after 2XPGF treatment (P< 0.05), and remained low until the end of the trial. P4 decreased in 1/6PGF between 8 and 16 h (P< 0.05), then began to rebound at 24 h. Luteal volume was higher in Controls at 48 h than at Oh. Under 1/6PGF, luteal volume decreased at 24 h (P <0.05) and began to rebound at 32 h. Luteal volume and blood flow were reduced starting at 24 and 32 h, respectively, after 2XPGF treatment (P< 0.05). In this study, we were able to describe the partial luteolysis phenomenon, induced by a treatment of a D6CL with cloprostenol sub-dose. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 12/18297-7 - Effect of heat stress on follicular development and luteolysis in Honstein cows, role of LH during induced luteolysis and characterization of luteal sensitivity to PGF2± during the estrous cycle
• Grantee: João Carlos Pinheiro Ferreira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/20449-7 - Role of LH during induced luteolysis and characterization of luteal sensitivity to PGF2alpha during estrus cycle and treatment with IFNt
• Grantee: Eduardo Trevisol
• Support Opportunities: Scholarships in Brazil - Doctorate