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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lewis-acid catalyzed N-acyliminium ion cyclodimerization: synthesis of symmetrical 1,4-dioxanes

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Author(s):
Ali, Bakhat [1] ; Zukerman-Schpector, Julio [2] ; Ferreira, Fernando P. [3] ; Shamim, Anwar [4] ; Pimenta, Daniel C. [5] ; Stefani, Helici A. [1, 4]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Inst Quim, Sao Paulo, SP - Brazil
[5] Inst Butantan, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Tetrahedron Letters; v. 56, n. 9, p. 1153-1158, FEB 25 2015.
Web of Science Citations: 4
Abstract

The cyclodimerization reaction of N-substituted-5-hydroxy-pyrrolydinones promoted by BF3 center dot Et2O and HCl to obtain symmetrical 1,4-dioxane derivatives was achieved in moderate to good yields, mild conditions, and short reaction times. These transformations render a promising alternative route that provides access to diverse 1,4-dioxane derivatives with a wide structural diversity. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/17954-4 - Cyclization reaction of Acetyl- and Ethylpyrrolidin-2-one with Potassium Organotrifluoroborate Salts
Grantee:Bakhat Ali
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/11499-0 - Bioisosterism in the design of new antichagasic agents: integration of computational and experimental strategies
Grantee:Gustavo Henrique Goulart Trossini
Support type: Regular Research Grants
FAPESP's process: 12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions
Grantee:Helio Alexandre Stefani
Support type: Research Projects - Thematic Grants