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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?

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de Carvalho-Ferreira, Joana Pereira [1] ; Landi Masquio, Deborah Cristina [2] ; da Silveira Campos, Raquel Munhoz [2] ; Netto, Barbara Dal Molin [2] ; Corgosinho, Flavia Campos [2] ; Sanches, Priscila L. [2] ; Tock, Lian [3] ; Tufik, Sergio [4] ; de Mello, Marco Tulio [4] ; Finlayson, Graham [5] ; Damaso, Ana R. [2, 1]
Total Authors: 11
[1] Univ Fed Sao Paulo, Postgrad Program Interdisciplinary Hlth Sci, BR-11060001 Santos, SP - Brazil
[2] Univ Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo, SP - Brazil
[3] Weight Sci, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP - Brazil
[5] Univ Leeds, Inst Psychol Sci, Leeds, W Yorkshire - England
Total Affiliations: 5
Document type: Journal article
Source: Peptides; v. 65, p. 20-28, MAR 2015.
Web of Science Citations: 8

Several studies have sought to clarify the association between adolescent obesity and psychological distress. Recently, a biological link between leptin resistance and depression has been proposed. The aim of the present study was to examine changes in leptin concentrations as a potential predictor of reduced depression symptoms in obese adolescents during long-term interdisciplinary weight loss therapy. Seventy-five obese adolescents (age: 16.28 +/- 2.37 years; BMI: 35.65 +/- 4.64 kg/m(2)) engaged in a long-term interdisciplinary therapy for weight loss. They were evaluated at baseline and after 1 year of treatment for body composition, serum analyses and depression symptomatology. After therapy, body mass BMI, fat mass (% and kg), waist circumference, visceral, subcutaneous and visceral/subcutaneous fat and depression symptoms decreased and lean mass (%) increased significantly. There was an improvement in inflammatory profiles with a significant reduction in leptin and increase in adiponectin. Regression analyses showed that decreased leptin predicted amelioration in depression symptoms independent of age, gender and changes in visceral fat, body mass, fat mass (%) and leptin/adiponectin ratio. These associations appear stronger in girls than boys. The attenuation of hyperleptinemia appears to play an important role in the association between weight loss and depression, particularly in obese girls. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants