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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dietary Docosahexaenoic Acid and Eicosapentaenoic Acid Influence Liver Triacylglycerol and Insulin Resistance in Rats Fed a High-Fructose Diet

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de Castro, Gabriela Salim [1, 2] ; Deminice, Rafael [3] ; Cordeiro Simoes-Ambrosio, Livia Maria [1] ; Calder, Philip C. [2] ; Jordao, Alceu A. [1] ; Vannucchi, Helio [1]
Total Authors: 6
[1] Univ Sao Paulo, Dept Internal Med, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Southampton, Human Dev & Hlth Acad Unit, Fac Med, Southampton SO16 6YD, Hants - England
[3] Univ Estadual Londrina, Dept Phys Educ, Fac Phys Educ & Sport, BR-86057970 Londrina, Parana - Brazil
Total Affiliations: 3
Document type: Journal article
Source: MARINE DRUGS; v. 13, n. 4, p. 1864-1881, 2015.
Web of Science Citations: 18

This study aimed to examine the benefits of different amounts of omega-3 (n-3) polyunsaturated fatty acids from fish oil (FO) on lipid metabolism, insulin resistance and gene expression in rats fed a high-fructose diet. Male Wistar rats were separated into two groups: Control (C, n = 6) and Fructose (Fr, n = 32), the latter receiving a diet containing 63% by weight fructose for 60 days. After this period, 24 animals from Fr group were allocated to three groups: FrFO2 (n = 8) receiving 63% fructose and 2% FO plus 5% soybean oil; FrFO5 (n = 8) receiving 63% fructose and 5% FO plus 2% soybean oil; and FrFO7 (n = 8) receiving 63% fructose and 7% FO. Animals were fed these diets for 30 days. Fructose led to an increase in liver weight, hepatic and serum triacylglycerol, serum alanine aminotransferase and HOMA1-IR index. These alterations were reversed by 5% and 7% FO. FO had a dose-dependent effect on expression of genes related to hepatic beta-oxidation (increased) and hepatic lipogenesis (decreased). The group receiving the highest FO amount had increased markers of oxidative stress. It is concluded that n-3 fatty acids may be able to reverse the adverse metabolic effects induced by a high fructose diet. (AU)

FAPESP's process: 11/10389-7 - Influence of n-3 fatty acids from fish oil on lipid metabolism and gene expression in rats with nonalcoholic fatty liver induced by fructose
Grantee:Helio Vannucchi
Support type: Regular Research Grants
FAPESP's process: 10/00408-1 - Effects of fish oil n-3 fatty acids on lipid metabolism and gene expression in rats fed a High-Fructose diet
Grantee:Gabriela Salim Ferreira de Castro
Support type: Scholarships in Brazil - Doctorate