The Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents

Author(s)

Cayres, Suziane Ungari ^{[1, 2]} ; de Lira, Fabio Santos ^{[1, 3]} ; Machado-Rodrigues, Aristides M. ^[4] ; Freitas Junior, Ismael Forte ^{[1, 3]} ; Barbosa, Mauricio Fregonesi ^[5] ; Fernandes, Romulo Araujo ^{[1, 2]}

Affiliation

^[1] Sao Paulo State Univ UNESP, Post Grad Program Movement Sci, Rio Claro - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Phys Educ, Lab Invest Exercise LIVE, Sao Paulo - Brazil

^[3] Sao Paulo State Univ UNESP, Dept Phys Educ, Immunometab Res Grp, Sao Paulo - Brazil

^[4] Univ Coimbra, Fac Sport Sci & Phys Educ, Coimbra - Portugal

^[5] Univ Fed Sao Paulo, UNIFESP, Program Postgrad Radiol, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF PEDIATRICS; v. 166, n. 4, p. 924-929, APR 2015.
• Web of Science Citations: 8

Abstract

Objective To analyze the relationship between inflammatory markers and the lipid profile, blood flow, and artery structure in prepubertal adolescents stratified according to sports practice. Study design The sample was composed of 120 adolescents (57 boys and 63 girls) with a mean age of 11.7 +/- 0.7 years (ranging from 11 to 13 years). Intima-media thickness (IMT) and blood flow were measured with ultrasonography. The lipid profile and high-sensitivity C-reactive protein were measured after the subjects had fasted for 12 hours overnight. Trunk fatness was measured by dual-energy x-ray absorptiometry. Organized sports participation was analyzed as a categorical variable. Biological maturation was determined via the age at peak height velocity. Results In the adjusted model, high-sensitivity C-reactive protein was significantly related to high-density lipoprotein-cholesterol (beta = -5.797 {[}-11.500 to -0.093]), femoral IMT (beta = 0.062 {[}0.008-0.116]), and the sum of femoral and carotid IMT (beta = 1.107 {[}0.223-1.919]), but only in the group without sports participation. Slopes of the crude linear regression were greater in the group without sports participation for femoral IMT (t = 2.621; P = .009) and the sum of femoral and carotid IMT (t = 2.876; P = .004) when compared with the group with sports participation. Conclusion Independent of body fatness and biological maturation, inflammatory status was related to artery IMT and dyslipidemia in prepubertal adolescents, modulated by sport participation. (AU)

• FAPESP's process: 13/06052-2 - Effect of behavioral habits and body fat on cardiovascular risk indicators among adolescents: cohort study 12 months
• Grantee: Suziane Ungari Cayres
• Support Opportunities: Scholarships in Brazil - Master