Quantification of nerolidol in mouse plasma using gas chromatography-mass spectrometry

Author(s)

Saito, Alexandre Yukio ^[1] ; Sussmann, Rodrigo Antonio Ceschini ^[1] ; Kimura, Emilia Akemi ^[1] ; Cassera, Maria Belen ^{[2, 3]} ; Katzin, Alejandro Miguel ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, BR-05508000 Sao Paulo, SP - Brazil

^[2] Virginia Tech, Dept Biochem, Blacksburg, VA 24061 - USA

^[3] Virginia Tech, Virginia Tech Ctr Drug Discovery, Blacksburg, VA 24061 - USA

• Document type: Journal article
• Source: Journal of Pharmaceutical and Biomedical Analysis; v. 111, p. 100-103, JUL 10 2015.
• Web of Science Citations: 3

Abstract

Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of flowers and plants. It is frequently used in cosmetics, as a food flavoring agent, and in cleaning products. In addition, nerolidol is used as a skin penetration enhancer for transdermal delivery of therapeutic drugs. However, nerolidol is hemolytic at low concentrations. A simple and fast GC-MS method was developed for preliminary quantification and assessment of biological interferences of nerolidol in mouse plasma after oral dosing. Calibration curves were linear in the concentration range of 0.010-5 mu g/mL nerolidol in mouse plasma with correlation coefficients (r) greater than 0.99. Limits of detection and quantification were 0.0017 and 0.0035 mu g/mL, respectively. The optimized method was successfully applied to the quantification of nerolidol in mouse plasma. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 14/23417-7 - Biosynthesis of isoprenoids in Plasmodium falciparum: evaluation of possible targets for to obtain new anti-malarial drugs
• Grantee: Alejandro Miguel Katzin
• Support Opportunities: Regular Research Grants