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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Silica, Hybrid Silica, Hydride Silica and Non-Silica Stationary Phases for Liquid Chromatography

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Author(s):
Borges, Endler M. [1]
Total Authors: 1
Affiliation:
[1] Univ Oeste Santa Catarina, Nucleo Biotecnol, BR-89560000 Videira, SC - Brazil
Total Affiliations: 1
Document type: Review article
Source: Journal of Chromatographic Science; v. 53, n. 4, p. 580-597, APR 2015.
Web of Science Citations: 10
Abstract

Free silanols on the surface of silica are the ``villains{''}, which are responsible for detrimental interactions of those compounds and the stationary phase (i.e., bad peak shape, low efficiency) as well as low thermal and chemical stability. For these reasons, we began this review describing new silica and hybrid silica stationary phases, which have reduced and/or shielded silanols. At present, in liquid chromatography for the majority of analyses, reversed-phase liquid chromatography is the separation mode of choice. However, the needs for increased selectivity and increased retention of hydrophilic bases have substantially increased the interest in hydrophilic interaction chromatography (HILIC). Therefore, stationary phases and this mode of separation are discussed. Then, non-silica stationary phases (i.e., zirconium oxide, titanium oxide, alumina and porous graphitized carbon), which afford increased thermal and chemical stability and also selectivity different from those obtained with silica and hybrid silica, are discussed. In addition, the use of these materials in HILIC is also reviewed. (AU)

FAPESP's process: 11/07466-0 - Determination of avermectins, milbemycins and amphenicols in fish filet: using LC-MS/MS
Grantee:Endler Marcel Borges de Souza
Support Opportunities: Scholarships in Brazil - Post-Doctoral