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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Structure and Absolute Configuration of Diterpenoids from Hymenaea stigonocarpa

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Monteiro, Afif F. [1] ; Batista, Jr., Joao M. [2] ; Machado, Michelle A. [1] ; Severino, Richele P. [1] ; Blanch, Ewan W. [3, 4] ; Bolzani, Vanderlan S. [2] ; Vieira, Paulo C. [5] ; Severino, Vanessa G. P. [1]
Total Authors: 8
[1] Univ Fed Goias, Unidade Acad Especial Fis & Quim, BR-75704020 Catalao, GO - Brazil
[2] Univ Estadual Paulista, Dept Quim Organ, BR-14800060 Araraquara, SP - Brazil
[3] Univ Manchester, Manchester Inst Biotechnol, Manchester M1 7DN, Lancs - England
[4] Univ Manchester, Fac Life Sci, Manchester M1 7DN, Lancs - England
[5] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Natural Products; v. 78, n. 6, p. 1451-1455, JUN 2015.
Web of Science Citations: 12

Chemical investigations of the ethanolic extracts from the flowers and leaves of Hymenaea stigonocarpa Mart. ex Hayne afforded one new ent-halimane diterpenoid, 18-hydroxy-ent-halima-1(10),13-(E)-dien-15-oic acid (1), together with five known compounds (2-6). The structural elucidation was performed by means of NMR (COSY, HSQC, HMBC, and NOESY) and MS analyses. Complete H-1 and C-13 NMR data assignments are also reported for labd-13-en-8 beta-ol-15-oic (2) and labd-7,13-dien-15-oic (3) acids. The absolute configurations of 1 and 2 were established by comparison of experimental and calculated Raman optical activity spectra. (AU)

FAPESP's process: 14/50304-9 - Stereochemical characterization of cyclotides from Cerrado species using Raman optical activity
Grantee:Vanderlan da Silva Bolzani
Support type: Regular Research Grants
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC