| Full text | |
| Author(s): |
Silva, Adriana F.
[1]
;
Alves, Falvio L.
[2]
;
Pedron, Cibele N.
[1]
;
Torres, Marcelo D. T.
[1]
;
Silva, Leandro S.
[3]
;
Pinheiro, Ana A. S.
[3]
;
Miranda, Antonio
[2]
;
Oliveira, Jr., Vani X.
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Fed ABC, BR-09210170 Santo Andre - Brazil
[2] Univ Fed Sao Paulo, BR-04044020 Sao Paulo - Brazil
[3] Univ Fed Rio de Janeiro, BR-21941902 Rio De Janeiro - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Bioorganic & Medicinal Chemistry Letters; v. 25, n. 16, p. 3311-3313, AUG 15 2015. |
| Web of Science Citations: | 2 |
| Abstract | |
To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P-2 analog presented high activity against Plasmodium gallinaceum, but they degrade in plasma. On the other hand, RI-BbKI did not degrade and reached high activity. No analog was active against Plasmodium falciparum. (C) 2015 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 11/15083-3 - Cyclic Antimalariais Derivates of Angiotensin II |
| Grantee: | Marcelo Der Torossian Torres |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 11/10823-9 - Antimalarial compounds derivative from angiotensin II |
| Grantee: | Vani Xavier de Oliveira Junior |
| Support Opportunities: | Regular Research Grants |