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Antimalarial Peptides derivative from Angiotensin II

Grant number: 11/11348-2
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2011
Effective date (End): August 31, 2015
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal researcher:Vani Xavier de Oliveira Junior
Grantee:Adriana Farias da Silva
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil

Abstract

Malaria is an acute febrile infectious disease, whose etiologic agent is the protozoan Plasmodium genus, being transmitted by Anopheles mosquitoes. The World Health Organization (WHO) has reported that 250 to 500 million people get malaria annually, resulting at least, in one million of deaths. Several chemotherapeutic agents have been used against this disease, however some have presented serious collateral effects or being become ineffective, because the parasites acquire resistance.Thus, some peptides have been studied, including angiotensin II (AII), which although it presents an antiplasmodial activity about 88% cannot be used as a drug because it has significant pressor activity. Therefore, some studies were performed with angiotensin II analogues, which filed suit antisporozoitic ranging between 67% and 87%, and no pressor activity.In order to obtain new effective chemotherapeutic agents against malaria, we propose in this paper a study of several antimalarial drugs, derived from the AII and known organic compounds. The peptides used in this work will be synthesized by solid phase method, purified by High Performance Liquid Chromatography (HPLC) and characterized by various analytical techniques. In the biological assays will verified the antimalarial activity of these compounds in P. gallinaceum, P. falciparum and P. chabaudi. Conformational studies will be performed by circular dichroism, and probably by nuclear magnetic ressonance.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, ADRIANA FARIAS; TOROSSIAN TORRES, MARCELO DER; SILVA, LEANDRO SOUZA; ALVES, FLAVIO LOPES; DE SA PINHEIRO, ANA ACACIA; MIRANDA, ANTONIO; CAPURRO, MARGARETH LARA; DE LA FUENTE-NUNEZ, CESAR; OLIVEIRA, JR., VANI XAVIER. Angiotensin II-derived constrained peptides with antiplasmodial activity and suppressed vasoconstriction. SCIENTIFIC REPORTS, v. 7, OCT 30 2017. Web of Science Citations: 4.
SILVA, ADRIANA FARIAS; TOROSSIAN TORRES, MARCELO DER; SILVA, LEANDRO DE SOUZA; ALVES, FLAVIO LOPES; DE SA PINHEIRO, ANA ACACIA; MIRANDA, ANTONIO; CAPURRO, MARGARETH LARA; OLIVEIRA, JR., VANI XAVIER. New linear antiplasmodial peptides related to angiotensin II. Malaria Journal, v. 14, NOV 4 2015. Web of Science Citations: 3.
SILVA, ADRIANA FARIAS; SILVA, LEANDRO DE SOUZA; ALVES, FLAVIO LOPES; TOROSSIANTORRES, MARCELO DER; DE SAPINHEIRO, ANA ACACIA; MIRANDA, ANTONIO; LARACAPURRO, MARGARETH; OLIVEIRA, JR., VANI XAVIER. Effects of the angiotensin II Ala-scan analogs in erythrocytic cycle of Plasmodium falciparum (in vitro) and Plasmodium gallinaceum (ex vivo). Experimental Parasitology, v. 153, p. 1-7, JUN 2015. Web of Science Citations: 2.

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