| Full text | |
| Author(s): |
Galvao Almeida, Nilsa Maria
[1]
;
Lima, Renata
[2]
;
Ribeiro Alves, Thais Francine
[1]
;
Rebelo, Marcia de Araujo
[1]
;
Severino, Patricia
[3]
;
Chaud, Marco Vinicius
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sorocaba, Dept Pharm, Lab Biomat & Nanotechnol, BR-18023000 Sorocaba, SP - Brazil
[2] Univ Sorocaba, Dept Biotechnol, Lab Biotechnol, BR-18023000 Sorocaba, SP - Brazil
[3] Univ Estadual Campinas, Dept Mat Sci & Bioproc Engn, Campinas, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Pharmaceutical Sciences; v. 51, n. 1, p. 91-100, JAN-MAR 2015. |
| Web of Science Citations: | 0 |
| Abstract | |
Bupropion is an antidepressant used in the treatment of smoking. The purpose of this study was to prepare controlled-release hydrogel films for buccal administration of bupropion and investigate its physicochemical and cytotoxic properties. The films were prepared from ultrapure sodium carboxymethylcellulose, hydroxypropylmethylcellulose K4M, and medium-viscosity chitosan. Evaluation of film physicochemical characteristics was based on scanning electron microscopy, bupropion content, mechanical strength (burst strength, relaxation, resilience, and traction), and cytotoxicity. Bupropion content in bilayer films was 121 mg per 9 cm2. The presence of bupropion modified film mechanical strength, but did not compromise the use of this pharmaceutical form. As shown by the cytotoxicity results, films containing bupropion did not cause cellular damage. Bupropion administration in the form of hydrogel films is a potentially useful alternative in the treatment of smoking. (AU) | |
| FAPESP's process: | 11/21219-5 - Preparation, in vitro characterization and in vivo evaluation of mucoadhesive polymer films in the prevention and treatment of acute oral mucositis induced by chemotherapy and radiotherapy |
| Grantee: | Marco Vinícius Chaud |
| Support Opportunities: | Regular Research Grants |