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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3 alpha

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Author(s):
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Fala, Angela M. [1] ; Oliveira, Juliana F. [1] ; Adamoski, Douglas [1] ; Aricetti, Juliana A. [2] ; Dias, Marilia M. [1] ; Dias, Marcio V. B. [1] ; Sforca, Maurcio L. [1] ; Lopes-de-Oliveira, Paulo S. [1] ; Rocco, Silvana A. [1] ; Caldana, Camila [2, 3] ; Dias, Sandra M. G. [1] ; Ambrosio, Andre L. B. [1]
Total Authors: 12
Affiliation:
[1] Ctr Nacl Pesquisa Energia & Mat, Lab Nacl Biociencias, BR-13083100 Campinas, SP - Brazil
[2] Ctr Nacl Pesquisa Energia & Mat, Lab Nacl Ciencia & Tecnol Bioetanol, BR-13083100 Campinas, SP - Brazil
[3] Max Plack Partner Grp, Lab Nacl Ciencia & Tecnol Bioetanol, Freiburg - Germany
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 5, AUG 3 2015.
Web of Science Citations: 7
Abstract

Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-alpha subunits is traditionally associated to post-translational modifications such as hydroxylation, acetylation, ubiquitination, and phosphorylation. Here we report novel evidence showing that unsaturated fatty acids are naturally occurring, non-covalent structural ligands of HIF-3 alpha, thus providing the initial framework for exploring its exceptional role as a lipid sensor under hypoxia. (AU)

FAPESP's process: 12/14298-9 - Cancer metabolic adaptation: structural and functional studies of key proteins
Grantee:Andre Luis Berteli Ambrosio
Support Opportunities: Regular Research Grants
FAPESP's process: 10/13739-6 - Establishing heterologous expression and purification conditions of the human hypoxia-inducible factor 1, HIF-1, for crystallographic studies.
Grantee:Angela Maria Fala
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/04927-4 - Identification of a novel cellular cofactor for the hypoxia-inducible transcription (HIF) and structural studies of the catalytic domains of isoforms 1 and 3 of the human prolyl-hydroxylases (PHD1 and PHD3) in complex with inhibitors
Grantee:Angela Maria Fala
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/20673-2 - Biophysical and biochemical studies of the mitochondrial pyruvate carrier (MPC) complex and the glutaminase enzyme bound to novel partners
Grantee:Andre Luis Berteli Ambrosio
Support Opportunities: Regular Research Grants
FAPESP's process: 14/15968-3 - Understanding the glutaminase functional regulation and the development of inhibitors as new approaches to cancer therapy
Grantee:Sandra Martha Gomes Dias
Support Opportunities: Regular Research Grants