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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intake of Passiflora edulis leaf extract improves antioxidant and anti-inflammatory status in rats with 2,4,6-trinitrobenzenesulphonic acid induced colitis

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Betim Cazarin, Cinthia Bau [1] ; da Silva, Juliana Kelly [1] ; Colomeu, Talita Cristina [2] ; Batista, Angela Giovana [1] ; Molina Meletti, Laura Maria [3] ; Rizzato Paschoal, Jonas Augusto [1] ; Bogusz Junior, Stanislau [4] ; de Campos Braga, Patricia Aparecida [1] ; Reyes Reyes, Felix Guillermo [1] ; Augusto, Fabio [5] ; de Meirelles, Luciana Rodrigues [2] ; Zollner, Ricardo de Lima [2] ; Marostica Junior, Mario Roberto [1]
Total Authors: 13
[1] Univ Estadual Campinas, Sch Food Engn, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Sao Paulo - Brazil
[3] Agron Inst Campinas, Ctr Res & Dev Plant Genet Resources, Campinas, SP - Brazil
[4] Univ Sao Paulo, Inst Chem Sao Carlos IQSC, Sao Paulo - Brazil
[5] Univ Estadual Campinas, Inst Chem, Inst Nacl Ciencia & Tecnol Bioanalit INCTBio, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Functional Foods; v. 17, p. 575-586, AUG 2015.
Web of Science Citations: 10

The antioxidant and anti-inflammatory effects of the aqueous extract of Passiflora edulis leaves, which is a source of vitexin, isovitexin and isoorientin, was investigated in a 2,4,6-trinitrobenzenesulphonic acid induced colitis model. The oral intake of P. edulis extract (1100 mu g mL(-1)) improved significantly (P < 0.05) the endogenous antioxidant status and decreased lipid peroxidation in serum, liver, and colon. The consumption of P. edulis extract decreased the level of pro-inflammatory in colon tissue, especially by reducing IL-1 beta fivefold and TNF-alpha two-fold compared to the control colitis group. The extract of P. edulis leaves possessed therapeutic activity in healthy rats and in TNBS-induced colitis, especially by controlling the oxidative stress and inflammation observed in this disease. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/16752-3 - Assessment of consumption of the peel of Passiflora edulis and its impact on intestinal inflammation in rats with ulcerative colitis.
Grantee:Cinthia Baú Betim Cazarin
Support type: Scholarships in Brazil - Doctorate