| Grant number: | 10/16752-3 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | March 01, 2011 |
| End date: | February 28, 2014 |
| Field of knowledge: | Health Sciences - Nutrition |
| Principal Investigator: | Mário Roberto Maróstica Junior |
| Grantee: | Cinthia Baú Betim Cazarin |
| Host Institution: | Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| Associated scholarship(s): | 12/24262-1 - Evaluation of the in vitro fermentation of passion fruit peel and its role in intestinal inflammation, BE.EP.DR |
Abstract Inflammatory bowel disease is a chronic relapsing disease that affects millions of people worldwide,encompassing Crohn's disease (CD) and ulcerative colitis (UC). The difference between these diseases is its location, and the UC-specific region is the colon and rectum. Current treatment for these diseases is carried out based on corticosteroids, immunomodulators or anti-TNF-alpha, known as biological therapy, which haveseveral adverse effects to the patient. The pathogenesis of this disease is related to genetic and environmental factors such as diet, smoking, drug use, stress and imbalance of the intestinal flora. It is thought that a break in the natural barrier exerted by the intestinal mucosa is the first step in triggering theinflammatory response. Once the protective barrier in the intestinal mucosa is destroyed, it turns susceptible to the effects caused by bacteria and substances present in the lumen translocation. Dietary fiber showsfunction on the modulation of microbiota and is used as substrate by microorganisms for the formation of short chain fatty acids, generated by the fermentation process. Several studies, using different sources of fiber, as well as butyrate enema, have shown positive effect in controlling the inflammatory process. Thus,this work is to evaluate the use of passion fruit peel as a source soluble fiber in the diet of rats with TNBS-induced colitis and its influence on the inflammatory process. Will be evaluated for composition of flour about the contents of dietary fiber, dietary indigestible fraction and antioxidant activity. In vivo assay will beevaluate the formation of short chain fatty acids, morphology of injured tissue, microbiota composition and activity of antioxidant enzymes, and expression of pro-inflammatory cytokines, expression of membrane receptors, MCP-1, Toll-like 2 and 4, the expression of iNOS, Cox-2 and NF-kB. | |
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