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Assessment of consumption of the peel of Passiflora edulis and its impact on intestinal inflammation in rats with ulcerative colitis

Grant number: 10/10131-7
Support type:Regular Research Grants
Duration: November 01, 2010 - October 31, 2013
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Mário Roberto Maróstica Junior
Grantee:Mário Roberto Maróstica Junior
Home Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers:Alba Regina Monteiro Souza Brito ; Anderson Luiz Ferreira ; Cinthia Baú Betim Cazarin ; Ricardo de Lima Zollner

Abstract

Inflammatory bowel disease is a chronic relapsing disease that affects millions of people worldwide, encompassing Crohn's disease (CD) and ulcerative colitis (UC). The difference between these diseases is its location, and the UC-specific region is the colon and rectum. Current treatment for these diseases is carried out based on corticosteroids, immunomodulators or anti-TNF-alpha, known as biological therapy, which have several adverse effects to the patient. The pathogenesis of this disease is related to genetic and environmental factors such as diet, smoking, drug use, stress and imbalance of the intestinal flora. It is thought that a break in the natural barrier exerted by the intestinal mucosa is the first step in triggering the inflammatory response. Once the protective barrier in the intestinal mucosa is destroyed, it turns susceptible to the effects caused by bacteria and substances present in the lumen translocation. Dietary fiber shows function on the modulation of microbiota and is used as substrate by microorganisms for the formation of short chain fatty acids, generated by the fermentation process. Several studies, using different sources of fiber, as well as butyrate enema, have shown positive effect in controlling the inflammatory process. Thus, this work is to evaluate the use of passion fruit peel as a source soluble fiber in the diet of rats with TNBS-induced colitis and its influence on the inflammatory process. Will be evaluated for composition of flour about the contents of dietary fiber, dietary indigestible fraction and antioxidant activity. In vivo assay will be evaluate the formation of short chain fatty acids, morphology of injured tissue, microbiota composition and activity of antioxidant enzymes, and expression of pro-inflammatory cytokines, expression of membrane receptors, MCP-1, Toll-like 2 and 4, the expression of iNOS, Cox-2 and NF-kB. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, JULIANA KELLY; BETIM CAZARIN, CINTHIA BAU; BATISTA, ANGELA GIOVANA; MAROSTICA, JR., MARIO. Effects of passion fruit (Passiflora edulis) byproduct intake in antioxidant status of Wistar rats tissues. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 59, n. 2, 2, SI, p. 1213-1219, DEC 2014. Web of Science Citations: 9.
DA SILVA, JULIANA KELLY; BETIM CAZARIN, CINTHIA BAU; BOGUSZ JUNIOR, STANISLAU; AUGUSTO, FABIO; MAROSTICA JUNIOR, MARIO ROBERTO. Passion fruit (Passiflora edulis) peel increases colonic production of short-chain fatty acids in Wistar rats. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 59, n. 2, 2, SI, p. 1252-1257, DEC 2014. Web of Science Citations: 12.

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