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Assessing the effects of yellow passion fruit peel flour (Passiflora edulis) in the treatment and / or prevention of obesity and comorbidities in vivo

Grant number: 12/12322-0
Support Opportunities:Regular Research Grants
Duration: September 01, 2012 - August 31, 2014
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Mário Roberto Maróstica Junior
Grantee:Mário Roberto Maróstica Junior
Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Currently, obesity is one of the most important problems of public health worldwide. Nutritional sciences have investigated foods; which may be adjuvants in current therapies, acting in the prevention of obesity and comorbidities. The passion fruit peel flour is a food rich in soluble and insoluble fiber and phenolic compounds. Therefore, it would be able to assist in improving some health parameters, such as modulation of microbiota and combating oxidative stress . This study aims to investigate the action of passion fruit peel flour on the molecular and physiological mechanisms, prevention and treatment of obesity in vivo. Three 'in vivo' experiments will be conducted to assess prebiotic and antioxidant effect of the passion fruit peel flour as supplementation in Swiss mice fed high-fat or pattern diet. The effects of the passion fruit peel flour on the modulation of the microbiota, SCFA production, gut hormones, serum adipokines, lipid profile, insulin resistance, modulation of gene expression and oxidative stress in animals will be assessed. The results will be submitted to analysis of variance (ANOVA) and treatment means will be compared by Tukey test (p<0.05) and the nonparametric by Kruskal-Wallis test (p<0.05). The project will run between the second half of 2012 and the first half of 2014. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VUOLO, MILENA MORANDI; LIMA, GLAUCIA CARIELO; BATISTA, ANGELA GIOVANA; BETIM CARAZIN, CINTHIA BAU; CINTRA, DENNYS ESPER; PRADO, MARCELO ALEXANDRE; MAROSTICA JUNIOR, MARIO ROBERTO. Passion fruit peel intake decreases inflammatory response and reverts lipid peroxidation and adiposity in diet-induced obese rats. Nutrition Research, v. 76, p. 106-117, . (18/11069-5, 12/12322-0, 15/50333-1)
LIMA, GLAUCIA CARIELO; VUOLO, MILENA MORANDI; BATISTA, ANGELA GIOVANA; DRAGANO, NATHALIA R. V.; SOLON, CARINA; MAROSTICA JUNIOR, MARIO ROBERTO. Passiflora edulis peel intake improves insulin sensitivity, increasing incretins and hypothalamic satietogenic neuropeptide in rats on a high-fat diet. NUTRITION, v. 32, n. 7-8, p. 863-870, . (12/12322-0)

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