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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fructooligosaccharide intake promotes epigenetic changes in the intestinal mucosa in growing and ageing rats

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Lima, Glaucia Carielo [1] ; Correa Vieira, Vivian Cristine [1] ; Betim Cazarin, Cinthia Bau [1] ; Ribeiro, Rafaela da Rosa [2] ; Bogusz Junior, Stanislau [3] ; de Albuquerque, Cibele Lima [2] ; Vidal, Ramon Oliveira [4] ; Netto, Claudia Cardoso [5] ; Yamada, Aureo Tatsumi [2] ; Augusto, Fabio [6] ; Marostica Junior, Mario Roberto [1, 7]
Total Authors: 11
[1] Univ Estadual Campinas, Sch Food Engn, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Campinas, SP - Brazil
[3] Univ Sao Paulo, Inst Chem, Sao Carlos, SP - Brazil
[4] Univ Montreal, St Justine Univ Hosp Ctr, Montreal, PQ - Canada
[5] Univ Fed Rio de Janeiro, Dept Biochem, Biol Sci & Hlth Ctr, Rio De Janeiro - Brazil
[6] Univ Estadual Campinas, Inst Chem, Campinas, SP - Brazil
[7] Univ Estadual Campinas, Fac Engn Alimentos, Dept Alimentos Nutr, Lab Nutr & Metab, R Monteiro Lobato 80, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: EUROPEAN JOURNAL OF NUTRITION; v. 57, n. 4, p. 1499-1510, JUN 2018.
Web of Science Citations: 2

Purpose The aim of this study was to investigate the relationship between fructooligosaccharide (FOS) intake at different life stages of Wistar rats and its stimulatory effects on intestinal parameters. Methods Recently weaned and ageing female rats were divided into growing and ageing treatments, which were fed diets that partially replaced sucrose with FOS for 12 weeks. Results Dietary FOS intake induced a significant increase in the numbers of Bifidobacterium and Lactobacillus in growing rats. FOS intake was associated with increased butyric acid levels and a reduced pH of the caecal contents at both ages. Differential gene expression patterns were observed by microarray analysis of growing and ageing animals fed the FOS diet. A total of 133 genes showed detectable changes in expression in the growing rats, while there were only 19 gene expression changes in ageing rats fed with FOS. Conclusion These results suggest that dietary FOS intake may be beneficial for some parameters of intestinal health in growing rats. (AU)

FAPESP's process: 10/05681-8 - Effect of non-digestible oligosaccharides FOS and GOS on the intestinal and bone metabolism of female Wistar rats on different years of age
Grantee:Mário Roberto Maróstica Junior
Support type: Regular Research Grants
FAPESP's process: 10/16752-3 - Assessment of consumption of the peel of Passiflora edulis and its impact on intestinal inflammation in rats with ulcerative colitis.
Grantee:Cinthia Baú Betim Cazarin
Support type: Scholarships in Brazil - Doctorate