Neglected diseases prioritized in Brazil under the perspective of metabolomics: A review

Author(s)

Canuto, Gisele A. B. ^[1] ; da Cruz, Pedro L. R. ^[1] ; Faccio, Andrea T. ^[1] ; Klassen, Aline ^[2] ; Tavares, Marina F. M. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Chem, BR-05508900 Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Diadema, SP - Brazil

• Document type: Review article
• Source: ELECTROPHORESIS; v. 36, n. 18, p. 2336-2347, SEP 2015.
• Web of Science Citations: 2

Abstract

This review article compiles in a critical manner literature publications regarding seven neglected diseases (ND) prioritized in Brazil (Chagas disease, dengue, leishmaniasis, leprosy, malaria, schistosomiasis, and tuberculosis) under the perspective of metabolomics. Both strategies, targeted and untargeted metabolomics, were considered in the compilation. The majority of studies focused on biomarker discovery for diagnostic purposes, and on the search of novel or alternative therapies against the ND under consideration, although temporal progression of the infection at metabolic level was also addressed. Tuberculosis, followed by schistosomiasis, malaria and leishmaniasis are the diseases that received larger attention in terms of number of publications. Dengue and leprosy were the least studied and Chagas disease received intermediate attention. NMR and HPLC-MS technologies continue to predominate among the analytical platforms of choice in the metabolomic studies of ND. A plethora of metabolites were identified in the compiled studies, with expressive predominancy of amino acids, organic acids, carbohydrates, nucleosides, lipids, fatty acids, and derivatives. (AU)

• FAPESP's process: 12/07361-6 - Mobility modulation in capillary electrophoresis
• Grantee: Marina Franco Maggi Tavares
• Support Opportunities: Regular Research Grants