Near Infrared Spectroscopy Detection and Quantification of Herbal Medicines Adulterated with Sibutramine

Author(s)

da Silva, Neirivaldo Cavalcante ^[1] ; Honorato, Ricardo Saldanha ^[2] ; Pimentel, Maria Fernanda ^[3] ; Garrigues, Salvador ^[4] ; Luisa Cervera, Maria ^[4] ; de la Guardia, Miguel ^[4]

Affiliation

^[1] Univ Fed Pernambuco, Dept Quim Fundamental, Recife, PE - Brazil

^[2] Superintendencia Reg Pernambuco, Dept Policia Fed, BR-50030230 Recife, PE - Brazil

^[3] Univ Fed Pernambuco, Dept Engn Quim, Recife, PE - Brazil

^[4] Univ Valencia, Dept Analyt Chem, Valencia - Spain

• Document type: Journal article
• Source: JOURNAL OF FORENSIC SCIENCES; v. 60, n. 5, p. 1199-1205, SEP 2015.
• Web of Science Citations: 5

Abstract

There is an increasing demand for herbal medicines in weight loss treatment. Some synthetic chemicals, such as sibutramine (SB), have been detected as adulterants in herbal formulations. In this study, two strategies using near infrared (NIR) spectroscopy have been developed to evaluate potential adulteration of herbal medicines with SB: a qualitative screening approach and a quantitative methodology based on multivariate calibration. Samples were composed by products commercialized as herbal medicines, as well as by laboratory adulterated samples. Spectra were obtained in the range of 14,000-4000 per cm. Using PLS-DA, a correct classification of 100% was achieved for the external validation set. In the quantitative approach, the root mean squares error of prediction (RMSEP), for both PLS and MLR models, was 0.2%w/w. The results prove the potential of NIR spectroscopy and multivariate calibration in quantifying sibutramine in adulterated herbal medicines samples. (AU)

• FAPESP's process: 08/57808-1 - National Institute of Advanced Analytical Science and Technology
• Grantee: Celio Pasquini
• Support type: Research Projects - Thematic Grants