Associations Between Sex Hormone Levels and Periodontitis in Men: Results From NHANES III

Author(s)

Steffens, Joao Paulo ^{[1, 2]} ; Wang, Xiaoshan ^[2] ; Starr, Jacqueline R. ^{[2, 3, 4]} ; Spolidorio, Luis Carlos ^[1] ; Van Dyke, Thomas E. ^[2] ; Kantarci, Alpdogan ^[2]

Affiliation

^[1] Univ Estadual Paulista, Sch Dent Araraquara, Dept Physiol & Pathol, Araraquara, SP - Brazil

^[2] Forsyth Inst, Ctr Periodontol, Dept Appl Oral Sci, Cambridge, MA - USA

^[3] Harvard Univ, Sch Dent Med, Dept Oral Hlth Policy & Epidemiol, Boston, MA 02115 - USA

^[4] Univ Washington, Dept Epidemiol, Seattle, WA 98195 - USA

• Document type: Journal article
• Source: Journal of Periodontology; v. 86, n. 10, p. 1116-1125, OCT 2015.
• Web of Science Citations: 8

Abstract

Background: Sex hormones are linked to inflammation and bone turnover. The goal of this study is to explore the association between sex hormone levels and periodontitis in men using data from the third National Health and Nutrition Examination Survey (NHANES III). Methods: Data from 755 men (aged >= 30 years), including serum levels of testosterone, estradiol, sex hormone binding globulin, and androstenediol glucuronide, were analyzed. Calculated bioavailable testosterone (CBT) and estradiol-to-testosterone ratio were calculated. Periodontitis was defined using the latest classification of extent and severity of periodontitis for NHANES data (>= 2 interproximal sites with >= 3 mm attachment loss, >= 2 interproximal sites with probing depth {[}PD] >= 4 mm not on the same tooth, or one site with PD >= 5 mm). Sex hormones were evaluated as categorized and continuous variables. Correlations between the presence and severity of periodontitis and levels of sex hormones were determined and expressed as odds ratios (ORs). Results: When adjusted for confounding factors, high total testosterone (TT) and CBT levels correlated with both the prevalence (OR {[}95% confidence interval (CI)], 2.1 {[}1 to 4.5] and 3.9 {[}1 to 14.8], respectively) and severity (OR {[}95% CI], 2.1 {[}1 to 4.3] and 3.4 {[}1.2 to 9.8]) of periodontitis. When continuous variables were used, the ORs (95% CIs) for presence and severity of periodontitis were 1.4 (0.6 to 3.3) and 1.5 (0.6 to 3.6) for TT and 1.3 (0.9 to 1.9) and 1.3 (0.9 to 1.8) for CBT, respectively. Conclusions: These findings are consistent with the existence of an association of periodontitis with sex hormone levels, especially testosterone, in men. (AU)

• FAPESP's process: 10/12021-4 - Effect of the testosterone levels reduction on the immunoinflammatory response associated with periodontal disease and rheumatoid arthritis induction in orchiectomized adult male rats
• Grantee: Luis Carlos Spolidorio
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/09658-0 - Effect of the reduction of testosterone level in the imunoinflammatory responses associated to periodontal disease and reumathoid arthritis due orquiectomy in rats
• Grantee: João Paulo Steffens
• Support Opportunities: Scholarships in Brazil - Doctorate