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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

PRELIMINARILY DEVELOPMENT OF A MOISTURE-ACTIVATED BIORESORBABLE POLYMERIC PLATFORM FOR DRUG DELIVERY

Full text
Author(s):
do Couto, Reno O. [1] ; Sommerfeld, Sven D. [2] ; Dube, Koustubh [2] ; de Freitas, Osvaldo [1] ; Kohn, Joachim [2]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Rutgers State Univ, Dept Chem & Chem Biol, New Jersey Ctr Biomat, Piscataway, NJ 08854 - USA
Total Affiliations: 2
Document type: Journal article
Source: Química Nova; v. 38, n. 7, p. 902-909, AUG 2015.
Web of Science Citations: 1
Abstract

Bioresorbable polymeric films were prepared by solvent casting using a tyrosine-derived polycarbonate and metronidazole (MDZ) as the model drug at 2.5%, 5% and 10% (w/w). Drug loading did not affect the water uptake, drug release, polymer degradation or erosion profiles. All devices released approximately 85% (w/w) of the drug within a 1.5 h period. This may be attributed to the rapid water uptake of the polymer. An increase in the water uptake correlated with a linear rate increase of the polymer degradation (0.968 <= R-2 = 0.999). Moreover, MDZ presented a remarkable plasticizing effect for the polymer and drug loading exerted a significant impact on the mechanical properties of the obtained films. The results obtained can be used to further the development of novel biocompatible and biodegradable polymeric platforms for the delivery of metronidazole and other drugs in a broad range of pharmaceutical applications. (AU)

FAPESP's process: 12/06167-1 - Development of mucoadhesive films for anesthetic release on the buccal cavity
Grantee:Renê Oliveira Do Couto
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/07251-6 - Development of platform with mucoadhesive systems for drug release on the buccal cavity
Grantee:Osvaldo de Freitas
Support Opportunities: Regular Research Grants
FAPESP's process: 13/12174-3 - Study of resorbable polymers: the effect of degradation and erosion on dye release
Grantee:Renê Oliveira Do Couto
Support Opportunities: Scholarships abroad - Research Internship - Doctorate