| Full text | |
| Author(s): |
Lourencao, Bruna C.
[1]
;
Medeiros, Roberta A.
[2, 1]
;
Thomasi, Sergio Scherrer
[1]
;
Ferreira, Antonio Gilberto
[1]
;
Rocha-Filho, Romeu C.
[1]
;
Fatibello-Filho, Orlando
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Estadual Oeste Parana, Ctr Engn & Ciencias Exatas, BR-85903000 Toledo, PR - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | SENSORS AND ACTUATORS B-CHEMICAL; v. 222, p. 181-189, JAN 2016. |
| Web of Science Citations: | 16 |
| Abstract | |
Sensitive, simple, low-cost, and rapid amperometric flow-injection methods were developed for determination of ivermectin (IVM) and levamisole (LVM) in anthelmintic pharmaceutical drugs and urine samples. These determinations were carried out with a cathodically (for IVM) or anodically (for LVM) pretreated boron-doped diamond electrode using aqueous 0.5 mol L-1 H2SO4 (with and without addition of 30% V/V of ethanol) as supporting electrolyte. The amperometric detection was performed at an applied electrode potential of E = 1.40V, for IVM, and E = 1.90V, for LVM, vs. Ag/AgCl (3.0 mol L-1 KCl). The respective analytical curves presented good linearity in the investigated concentration ranges (0.60-50 mu mol L-1, for IVM, and 0.010-5.0 mu mol L-1; for LVM) and the detection limits were 0.30 mu mol L-1 for IVM, and 1 nmol L-1, for LVM. Investigation of possible interferents showed no significant interference with the here-proposed methods; thus, they were used to determine IVM and LVM in pharmaceutical formulations as well as in urine samples, with results that showed good agreement with comparative methods. Furthermore, a mechanism for LVM electrooxidation was proposed using exhaustive potentiostatic electrolysis and NMR measurements. (C) 2015 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 09/17729-8 - Boron-Doped Diamond Electrode for the Determination Voltametric/ Amperometric of Anti-Helmintic and antihypertensive Drugs |
| Grantee: | Bruna Cláudia Lourenção |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/03019-7 - Evaluation and analytical application of boron doped diamond porous electrodes for voltammetric determination of biomolecules, ascorbic acid, uric acid, dopamine and adrenaline in biological fluids and/or pharmaceutical formulations |
| Grantee: | Bruna Cláudia Lourenção |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 11/00601-9 - Application of boron-doped diamond and amorphous carbon nitride electrodes for the simultaneous determination of drugs of different therapeutic groups in pharmaceutical formulations and urine samples |
| Grantee: | Roberta Antigo Medeiros |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |