Nitroprusside as a Novel Reagent for Flow Injection Spectrophotometric Determination of Captopril

Author(s)

de Oliveira, Denilson Mendes ^[1] ; Suarez, Willian Toito ^[1] ; Alvarenga Junior, Benedito Roberto ^[1] ; Gabriel, Wesley Lira ^[1] ; dos Santos, Vagner Bezerra ^[2]

Affiliation

^[1] Univ Fed Vicosa, Dept Chem, BR-36570900 Vicosa, MG - Brazil

^[2] Univ Sao Paulo, Inst Chem, Sao Paulo - Brazil

• Document type: Journal article
• Source: Analytical Letters; v. 49, n. 2, p. 200-207, JAN 22 2016.
• Web of Science Citations: 2

Abstract

A novel flow injection system for the determination of captopril in pharmaceutical formulations is described. Nitroprusside was employed as a new, nontoxic reagent. Captopril reacted with nitroprusside in basic solution to yield a red chromophore with maximum absorbance at 521nm. The calibration relationship was linear for concentrations from 3.0x10(-6) to 1.0x10(-3)molL(-1) with a limit of detection of 1.0x10(-6)molL(-1). The recoveries from captopril tablets were between 99.7 and 102.3%. The sampling frequency was 50h(-1) and the relative standard deviation was estimated to be 1.0% for 5.0x10(-4)molL(-1) captopril. A paired t-test showed that analysis of tablets by the flow procedure and a potentiometry provided similar results at the 95% confidence level. (AU)

• FAPESP's process: 13/14993-1 - Characterization and quantification of monoalkyl carbonates in aqueous medium employing microfluidic devices coupled to a mass spectrometer
• Grantee: Vagner Bezerra dos Santos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral