Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Structure and Biogenesis of Roussoellatide, a Dichlorinated Polyketide from the Marine-Derived Fungus Roussoella sp DLM33

Full text
Author(s):
Show less -
Ferreira, Everton L. F. [1] ; Williams, David E. [2, 3] ; Ioca, Laura P. [1] ; Morais-Urano, Raquel P. [1] ; Santos, Mario F. C. [1] ; Patrick, Brian O. [2, 3] ; Elias, Luciana M. [4] ; Lira, Simone P. [4] ; Ferreira, Antonio G. [5] ; Passarini, Michel R. Z. [6] ; Sette, Lara D. [7] ; Andersen, Raymond J. [2, 3] ; Berlinck, Roberto G. S. [1]
Total Authors: 13
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ British Columbia, Dept Chem & Earth, Vancouver, BC V6T 1Z1 - Canada
[3] Univ British Columbia, Dept Ocean & Atmospher Sci, Vancouver, BC V6T 1Z1 - Canada
[4] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Ciencias Exatus, BR-13418900 Piracicaba, SP - Brazil
[5] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[6] Univ Estadual Campinas, Div Recursos Microbianos, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, BR-13140000 Paulinia, SP - Brazil
[7] Univ Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, BR-1515 Rio Claro, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: ORGANIC LETTERS; v. 17, n. 21, p. 5152-5155, NOV 6 2015.
Web of Science Citations: 8
Abstract

The structure of the fungal metabolite roussoellatide (1) has been established by spectroscopic and X-ray diffraction analyses. Results from feeding experiments with {[}1-C-13]acetate, {[}2-C-13]acetate, and {[}1,2-C-13]acetate were consistent with a biosynthetic pathway to the unprecedented skeleton of 1 involving Favorskii rearrangements in separate pentaketides, subsequently joined via an intermolecular Diels-Alder reaction. (AU)

FAPESP's process: 12/50026-3 - International collaboration in the chemistry of alkaloid natural product biosynthesis
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: Regular Research Grants
FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants