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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Structure and Biogenesis of Roussoellatide, a Dichlorinated Polyketide from the Marine-Derived Fungus Roussoella sp DLM33

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Author(s):
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Ferreira, Everton L. F. [1] ; Williams, David E. [2, 3] ; Ioca, Laura P. [1] ; Morais-Urano, Raquel P. [1] ; Santos, Mario F. C. [1] ; Patrick, Brian O. [2, 3] ; Elias, Luciana M. [4] ; Lira, Simone P. [4] ; Ferreira, Antonio G. [5] ; Passarini, Michel R. Z. [6] ; Sette, Lara D. [7] ; Andersen, Raymond J. [2, 3] ; Berlinck, Roberto G. S. [1]
Total Authors: 13
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ British Columbia, Dept Chem & Earth, Vancouver, BC V6T 1Z1 - Canada
[3] Univ British Columbia, Dept Ocean & Atmospher Sci, Vancouver, BC V6T 1Z1 - Canada
[4] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Ciencias Exatus, BR-13418900 Piracicaba, SP - Brazil
[5] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[6] Univ Estadual Campinas, Div Recursos Microbianos, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, BR-13140000 Paulinia, SP - Brazil
[7] Univ Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, BR-1515 Rio Claro, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: ORGANIC LETTERS; v. 17, n. 21, p. 5152-5155, NOV 6 2015.
Web of Science Citations: 8
Abstract

The structure of the fungal metabolite roussoellatide (1) has been established by spectroscopic and X-ray diffraction analyses. Results from feeding experiments with {[}1-C-13]acetate, {[}2-C-13]acetate, and {[}1,2-C-13]acetate were consistent with a biosynthetic pathway to the unprecedented skeleton of 1 involving Favorskii rearrangements in separate pentaketides, subsequently joined via an intermolecular Diels-Alder reaction. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands
Grantee:Roberto Gomes de Souza Berlinck
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 12/50026-3 - International collaboration in the chemistry of alkaloid natural product biosynthesis
Grantee:Roberto Gomes de Souza Berlinck
Support type: Regular Research Grants