Study of marine-derived microrganisms metabolism: chemical profile and biosynthesis
| Full text | |
| Author(s): Show less - |
Ferreira, Everton L. F.
[1]
;
Williams, David E.
[2, 3]
;
Ioca, Laura P.
[1]
;
Morais-Urano, Raquel P.
[1]
;
Santos, Mario F. C.
[1]
;
Patrick, Brian O.
[2, 3]
;
Elias, Luciana M.
[4]
;
Lira, Simone P.
[4]
;
Ferreira, Antonio G.
[5]
;
Passarini, Michel R. Z.
[6]
;
Sette, Lara D.
[7]
;
Andersen, Raymond J.
[2, 3]
;
Berlinck, Roberto G. S.
[1]
Total Authors: 13
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ British Columbia, Dept Chem & Earth, Vancouver, BC V6T 1Z1 - Canada
[3] Univ British Columbia, Dept Ocean & Atmospher Sci, Vancouver, BC V6T 1Z1 - Canada
[4] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Ciencias Exatus, BR-13418900 Piracicaba, SP - Brazil
[5] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[6] Univ Estadual Campinas, Div Recursos Microbianos, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, BR-13140000 Paulinia, SP - Brazil
[7] Univ Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, BR-1515 Rio Claro, SP - Brazil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | ORGANIC LETTERS; v. 17, n. 21, p. 5152-5155, NOV 6 2015. |
| Web of Science Citations: | 8 |
| Abstract | |
The structure of the fungal metabolite roussoellatide (1) has been established by spectroscopic and X-ray diffraction analyses. Results from feeding experiments with {[}1-C-13]acetate, {[}2-C-13]acetate, and {[}1,2-C-13]acetate were consistent with a biosynthetic pathway to the unprecedented skeleton of 1 involving Favorskii rearrangements in separate pentaketides, subsequently joined via an intermolecular Diels-Alder reaction. (AU) | |
| FAPESP's process: | 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support type: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 12/50026-3 - International collaboration in the chemistry of alkaloid natural product biosynthesis |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support type: | Regular Research Grants |