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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Low Level Laser Therapy Reduces the Development of Lung Inflammation Induced by Formaldehyde Exposure

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Author(s):
da Silva, Cristiane Miranda [1] ; Leal, Mayara Peres [1] ; Brochetti, Robson Alexandre [1] ; Braga, Tarcio [2] ; Vitoretti, Luana Beatriz [1] ; Saraiva Camara, Niels Olsen [2] ; Damazo, Amilcar Sabino [3] ; Ligeiro-de-Oliveira, Ana Paula [1] ; Chavantes, Maria Cristina [4] ; Lino-dos-Santos-Franco, Adriana [1]
Total Authors: 10
Affiliation:
[1] Univ Nove de Julho UNINOVE, Post Grad Program Biophoton Appl Hlth Sci, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Immunol, Sao Paulo - Brazil
[3] Fed Univ Cuiaba, Dept Basic Sci Hlth, Fac Med Sci, Cuiaba - Brazil
[4] Univ Nove de Julho UNINOVE, Post Grad Program Med, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PLoS One; v. 10, n. 11 NOV 16 2015.
Web of Science Citations: 19
Abstract

Lung diseases constitute an important public health problem and its growing level of concern has led to efforts for the development of new therapies, particularly for the control of lung inflammation. Low Level Laser Therapy (LLLT) has been highlighted as a non-invasive therapy with few side effects, but its mechanisms need to be better understood and explored. Considering that pollution causes several harmful effects on human health, including lung inflammation, in this study, we have used formaldehyde (FA), an environmental and occupational pollutant, for the induction of neutrophilic lung inflammation. Our objective was to investigate the local and systemic effects of LLLT after FA exposure. Male Wistar rats were exposed to FA (1%) or vehicle (distillated water) during 3 consecutive days and treated or not with LLLT (1 and 5 hours after each FA exposure). Non-manipulated rats were used as control. 24 h after the last FA exposure, we analyzed the local and systemic effects of LLLT. The treatment with LLLT reduced the development of neutrophilic lung inflammation induced by FA, as observed by the reduced number of leukocytes, mast cells degranulated, and a decreased myeloperoxidase activity in the lung. Moreover, LLLT also reduced the microvascular lung permeability in the parenchyma and the intrapulmonary bronchi. Alterations on the profile of inflammatory cytokines were evidenced by the reduced levels of IL-6 and TNF-alpha and the elevated levels of IL-10 in the lung. Together, our results showed that LLLT abolishes FA-induced neutrophilic lung inflammation by a reduction of the inflammatory cytokines and mast cell degranulation. This study may provide important information about the mechanisms of LLLT in lung inflammation induced by a pollutant. (AU)

FAPESP's process: 11/51711-9 - Exposure to ambient and occupational pollution in uterus and its repercussion on development of allergic lung inflammation in offspring: correlation with epigenetic mechanisms
Grantee:Adriana Lino dos Santos Franco
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 12/16498-5 - Effect of low level laser therapy in experimental models of pulmonary chronic diseases
Grantee:Ana Paula Ligeiro de Oliveira
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 15/00830-9 - Effects of exposure to ambient/occupational pollution on idiopathic pulmonary fibrosis
Grantee:Adriana Lino dos Santos Franco
Support Opportunities: Regular Research Grants