Scale-up study of supercritical fluid extraction process for Baccharis dracunculifolia

Author(s)

Paula, Julia T. ^[1] ; Aguiar, Ana C. ^[1] ; Sousa, Ilza M. O. ^[2] ; Magalhaes, Pedro M. ^[2] ; Foglio, Mary A. ^[2] ; Cabral, Fernando A. ^[1]

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Dept Food Engn, BR-13083862 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Chem Biol & Agr Pluridisciplinary Res Ctr CPQBA, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF SUPERCRITICAL FLUIDS; v. 107, p. 219-225, JAN 2016.
• Web of Science Citations: 12

Abstract

To evaluate the effects of the bed geometry on the scale-up of fixed bed extractors and on the cost of supercritical extracts from Baccharis dracunculifolia leaves (local name in Brazil: alecrim-do-campo), supercritical CO2 (scCO(2)) extraction curves at 50 degrees C and 300 bar at different heights (H) and bed diameter (D), at HID ratio ranging from 1.86 to 5.2 were obtained. The global yield in all experiments was around 4.6%, and the scale-up criterion adopted was maintain constant the solvent flux. Five phenolic compounds of interest, caffeic acid, p-coumaric acid, trans-cinnamic acid, artepillin C, and kaempferide were quantified by high-performance liquid chromatography. The fractions exhibited high kaempferide levels, which varied from 29.07 to 46.47 mg kaempferide per gram of extract. The optimal manufacturing cost has been estimated at US \$ 171.12/kg at 80 min, which shows the possibility of obtaining B. dracunculifolia extracts at an industrial level. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 12/51317-1 - Development of products and processes with supercritical technology: construction of one multipurpose unit to obtain extracts of industrial interest.
• Grantee: Fernando Antonio Cabral
• Support Opportunities: Regular Research Grants