Evaluation of acute effect of light-emitting diode (LED) phototherapy on muscle deoxygenation and pulmonary oxygen uptake kinetics in patients with diabetes mellitus: study protocol for a randomized controlled trial

Author(s)

Francisco, Cristina de Oliveira ^[1] ; Beltrame, Thomas ^[2] ; Ferraresi, Cleber ^[3] ; Parizotto, Nivaldo Antonio ^[1] ; Bagnato, Vanderlei Salvador ^[4] ; Silva, Audrey Borghi ^[1] ; Benze, Benedito Galvao ^[5] ; Porta, Alberto ^{[6, 7]} ; Catai, Aparecida Maria ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Physiotherapy, BR-13565905 Sao Paulo - Brazil

^[2] Univ Waterloo, Fac Appl Hlth Sci, Waterloo, ON N2L 3G1 - Canada

^[3] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 - USA

^[4] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Paulo - Brazil

^[5] Univ Fed Sao Carlos, Dept Stat, BR-13565905 Sao Paulo - Brazil

^[6] Univ Milan, Dept Biomed Sci Hlth, I-20122 Milan - Italy

^[7] Policlin San Donato, Dept Cardiothorac Vasc Anesthesia & Intens Care, IRCCS, Milan - Italy

• Document type: Journal article
• Source: Trials; v. 16, DEC 15 2015.
• Web of Science Citations: 2

Abstract

Background: Type 2 diabetes mellitus (DM) is responsible for a significant reduction in the quality of life due to its negative impact on functional capacity. Cardiopulmonary fitness impairment in DM patients has been associated with limited tissue oxygenation. Phototherapy is widely utilized to treat several disorders due to expected light-tissue interaction. This type of therapy may help to improve muscular oxygenation, thereby increasing aerobic fitness and functional capacity. Methods/Design: This study is a randomized, double-blind, placebo-controlled crossover trial approved by the Ethics Committee of the Federal University of Sao Carlos and registered at ClinicalTrials.gov. Four separate tests will be performed to evaluate the acute effect of phototherapy. All participants will receive both interventions in random order: light-emitting diode therapy (LEDT) and placebo, with a minimum 14-day interval between sessions (washout period). Immediately after the intervention, participants will perform moderate constant workload cycling exercise corresponding to 80 % of the pulmonary oxygen uptake (p(V) over dotO(2)) during the gas exchange threshold (GET). LEDT will be administered with a multidiode cluster probe (50 GaAIA LEDs, 850 eta m, 75 mW each diode, and 3 J per point) before each exercise session. Pulmonary oxygen uptake, muscle oxygenation, heart rate, and arterial pressure will be measured using a computerized metabolic cart, a near-infrared spectrometer, an electrocardiogram, and a photoplethysmography system, respectively. Discussion: The main objective of this study is to evaluate the acute effects of muscular pre-conditioning using LED phototherapy on pulmonary oxygen uptake, muscle oxygenation, heart rate, and arterial pressure dynamics during dynamic moderate exercise. We hypothesize that phototherapy may be beneficial to optimize aerobic fitness in the DM population. Data will be published after the study is completed. (AU)

• FAPESP's process: 13/07953-3 - Evaluation of acute effect of phototherapy with Light Emitting Diode (led) on muscle and pulmonary oxygen consumption in patients with diabetes mellitus
• Grantee: Aparecida Maria Catai
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/08183-7 - Acute effect of phototherapy with light emitting diode (LED) on muscle and pulmonary oxygen consumption in men with diabetes mellitus and healthy
• Grantee: Cristina de Oliveira Francisco
• Support Opportunities: Scholarships in Brazil - Doctorate