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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial

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Author(s):
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Andrade e Silva, Bruna [1] ; Cassilhas, Ricardo C. [2, 3] ; Attux, Cecilia [4] ; Cordeiro, Quirino [5] ; Gadelha, Andre L. [4] ; Telles, Bruno A. [4] ; Bressan, Rodrigo A. [4] ; Ferreira, Francine N. [4] ; Rodstein, Paulo H. [4] ; Daltio, Claudiane S. [4] ; Tufik, Sergio [2] ; de Mello, Marco T. [6]
Total Authors: 12
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Nutr, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP - Brazil
[3] Univ Fed Vales Jequitinhonha & Mucuri, Dept Phys Educ, Diamantina, MG - Brazil
[4] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, SP - Brazil
[5] FCMSCSP, Sao Paulo, SP - Brazil
[6] Univ Fed Minas Gerais, Belo Horizonte, MG - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Revista Brasileira de Psiquiatria; v. 37, n. 4, p. 271-279, OCT-DEC 2015.
Web of Science Citations: 17
Abstract

Objective: To evaluate the effects of 20 weeks of resistance and concurrent training on psychotic and depressive symptoms, quality of life outcomes, and serum IGF-1, IGFBP-3, and brain-derived neurotrophic factor (BDNF) concentrations in patients with schizophrenia. Methods: In this blind, randomized controlled clinical trial, 34 patients with schizophrenia were assigned to one of three groups: control (CTRL, n=13), resistance exercise (RESEX, n=12), or concurrent exercise (CONCEX, n=9). Symptoms, quality of life, strength, and other variables were assessed. Results: A significant time-by-group interaction was found for the RESEX and CONCEX groups on the Positive and Negative Syndrome Scale (PANSS) total score for disease symptoms (p = 0.007), positive symptoms (p = 0.003), and on the arm extension one-repetition maximum (1RM) test (p = 0.016). In addition, significant improvements on negative symptoms (p = 0.027), on the role-physical domain of the Short Form-36 Health Survey (p = 0.019), and on the chest press 1RM test (p = 0.040) were observed in the RESEX group. No changes were observed for the other variables investigated. Conclusions: In this sample of patients with schizophrenia, 20 weeks of resistance or concurrent exercise program improved disease symptoms, strength, and quality of life. ClinicalTrials.gov: NCT01674543. (AU)

FAPESP's process: 13/05018-5 - Exercise, pollution and the brain: influence on sleep and cognition
Grantee:Ricardo Cardoso Cassilhas
Support Opportunities: Scholarships in Brazil - Post-Doctoral