Estrogenic activities of diuron metabolites in female Nile tilapia (Oreochromis niloticus)

Author(s)

Boscolo Pereira, Thiago Scremin ^[1] ; Pereira Boscolo, Camila Nomura ^[1] ; Felicio, Andreia Arantes ^[2] ; Batlouni, Sergio Ricardo ^[3] ; Schlenk, Daniel ^[4] ; de Almeida, Eduardo Alves ^[2]

Affiliation

^[1] Univ Estadual Paulista IBILCE UNESP, Dept Zool & Bot, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[2] Univ Estadual Paulista IBILCE UNESP, Dept Chem & Environm Sci, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Univ Estadual Paulista CAUNESP, Aquaculture Ctr, Via Acesso Prof Paulo Donato Castelane S-N, BR-14884900 Jaboticabal, SP - Brazil

^[4] Univ Calif Riverside, Dept Environm Sci, 3401 Watkins Dr, Riverside, CA 92521 - USA

• Document type: Journal article
• Source: Chemosphere; v. 146, p. 497-502, MAR 2016.
• Web of Science Citations: 11

Abstract

Some endocrine disrupting chemicals (EDCs) can alter the estrogenic activities of the organism by directly interacting with estrogen receptors (ER) or indirectly through the hypothalamus-pituitary gonadal axis. Recent studies in male Nile tilapia (Oreochromis niloticus) indicated that diuron may have anti-androgenic activity augmented by biotransformation. In this study, the effects of diuron and three of its metabolites were evaluated in female tilapia. Sexually mature female fish were exposed for 25 days to diuron, as well as to its metabolites 3,4-dichloroaniline (DCA), 3,4-dichlorophenylurea (DCPU) and 3,4-dichlorophenyl-N-methylurea (DCPMU), at concentrations of 100 ng/L. Diuron metabolites caused increases in E-2 plasma levels, gonadosomatic indices and in the percentage of final vitellogenic oocytes. Moreover, diuron and its metabolites caused a decrease in germinative cells. Significant differences in plasma concentrations of the estrogen precursor and gonadal regulator17 alpha-hydroxyprogesterone (17 alpha-OHP) were not observed. These results show that diuron metabolites had estrogenic effects potentially mediated through enhanced estradiol biosynthesis and accelerated the ovarian development of O. niloticus females. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 11/52061-8 - Biochemical and estrogenic effects of Diuron and its metabolites, alone or in combination with alkylphenols in Nile Tilapia (Oreochromis niloticus)
• Grantee: Eduardo Alves de Almeida
• Support Opportunities: Program for Research on Bioenergy (BIOEN) - Regular Program Grants