Physical Activity Modifies the Associations between Genetic Variants and Blood Pressure in European Adolescents

Author(s):Show less -

Ferreira de Moraes, Augusto Cesar ^{[1, 2, 3]} ; Miguel Fernandez-Alvira, Juan ^{[2, 3]} ; Carvalho, Heraclito Barbosa ^[1] ; Meirhaeghe, Aline ^{[4, 5]} ; Dallongeville, Jean ^{[4, 5]} ; Kafatos, Anthony ^[6] ; Marcos, Ascension ^[7] ; Molnar, Denes ^[8] ; Manios, Yannis ^[9] ; Ruiz, Jonatan R. ^[10] ; Labayen, Idoia ^[11] ; Widhalm, Kurt ^[12] ; Breidenassel, Christina ^[13] ; Gonzalez-Gross, Marcela ^{[14, 13]} ; Moreno, Luis A. ^{[2, 3]}

Affiliation:Show less -

^[1] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil

^[2] Univ Zaragoza, Fac Hlth Sci, Zaragoza - Spain

^[3] Univ Zaragoza, GENUD Growth Exercise Nutr & Dev Res Grp, Zaragoza - Spain

^[4] Univ Lille Nord France, Inst Pasteur Lille, INSERM, U744, Lille - France

^[5] UDSL, Lille - France

^[6] Univ Crete, Prevent Med & Nutr Unit, Sch Med, Iraklion, Crete - Greece

^[7] Spanish Natl Res Council, Dept Metab & Nutr, Food Sci & Technol & Nutr Inst, Immunonutr Res Grp, Madrid - Spain

^[8] Univ Pecs, Fac Med, Dept Pediat, Pecs - Hungary

^[9] Harokopio Univ, Dept Nutr & Dietet, Athens - Greece

^[10] Univ Granada, Fac Sport Food Sci, Dept Phys Educ & Sports, Promoting Fitness & Hlth Phys Act Res Grp, Granada - Spain

^[11] Univ Basque Country, Dept Nutr & Food Sci, Vitoria - Spain

^[12] Private Med Univ Salzburg, Dept Pediat, Salzburg - Austria

^[13] Univ Bonn, Inst Ernahrungs & Lebensmittelwissensch Humanerna, Bonn - Germany

^[14] Tech Univ Madrid, Fac Phys Act & Sport INEF, Dept Hlth & Human Performance, Madrid - Spain

• Document type: Journal article
• Source: JOURNAL OF PEDIATRICS; v. 165, n. 5, p. 1046-U237, NOV 2014.
• Web of Science Citations: 3

Abstract

We hypothesized that physical activity and sedentary behavior could modify the associations between known genetic variants blood pressure-associated genes in European adolescents. Meeting current physical activity recommendations (>= 60 minutes/day) was able attenuate the deleterious effect of the NOS3 rs3918227 polymorphism on systolic blood pressure in European adolescents. (AU)

• FAPESP's process: 11/11137-1 - High blood pressure and aggregation of risk factors in adolescents: a multicenter study
• Grantee: Augusto César Ferreira de Moraes
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 11/20662-2 - High blood pressure and aggregation of risk factors in adolescents: a multicenter study
• Grantee: Augusto César Ferreira de Moraes
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate