Exercise training and taurine supplementation reduce oxidative stress and prevent endothelium dysfunction in rats fed a highly palatable diet

Author(s)

Oharomari, Leandro Kansuke ^[1] ; Garcia, Nadia Fagundes ^[2] ; de Freitas, Ellen Cristini ^[2] ; Jordao Junior, Alceu Afonso ^[1] ; Ovidio, Paula Payao ^[1] ; Maia, Aline Rosa ^[3] ; Davel, Ana Paula ^[3] ; de Moraes, Camila ^[2]

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Lab Nutr & Metab, BR-05508 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-05508 Sao Paulo, SP - Brazil

^[3] Univ Estadual Campinas, Dept Struct & Funct Biol, Campinas, SP - Brazil

• Document type: Journal article
• Source: Life Sciences; v. 139, p. 91-96, OCT 15 2015.
• Web of Science Citations: 6

Abstract

Aim: Few studies have analysed, from a nutritional point of view, the influence of exercise in minimizing detrimental diet-related health effects. This study evaluated the effectiveness of exercise and taurine supplementation in preventing vascular and metabolic disorders caused by highly palatable diet intake. Main methods: Thirty-two male Wistar rats (255-265 g) were divided into 4 groups: Sedentary (SD); Sedentary + 2% taurine (SDTAU), Trained (TR) and Trained + 2% taurine (TRTAU). Exercise (treadmill, 60% maximum speed, 60 min, 5 days/week) started after 4 weeks of highly palatable diet feeding and was carried out for 7 weeks. Key findings: Exercise effectively reduced insulin (61% and 68%), glucose (30% and 7%) and leptin levels (75% and 67%) in TR and TRTAU groups, respectively. All groups showed a reduction in hepatic triglyceride infiltration (74% for SDTAU, 82% for TR and 85% for TRTAU) but only exercise reduced TBARS (50% for TR and 41% for TRTAU). Impaired relaxation was seen in SD (E-max = 67%) and improved with taurine (E-max = 86%) and exercise (E-max = 90% for TR and TRTAU). Increased expression of EC-SOD (32%) was seen in the aortas from all treated groups. Exercise, in the absence of taurine, increased Cu-Zn SOD (44%) and reduced gp91(phox) (34%). Superoxide formation in the aorta was reduced in supplemented (75% in SDTAU) and in trained groups (64% and 77% for TR and TRTAU, respectively). Significance: Exercise and taurine supplementation were effective in preventing endothelial dysfunction induced by highly palatable diet intake, through a decrease in vascular oxidative stress. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 10/12733-4 - Relaxation and contractile responses of aorta and mesenteric arteries from obese rats supplemented with taurine and trained
• Grantee: Camila de Moraes
• Support Opportunities: Regular Research Grants