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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of gestational diabetes and lactational insulin replacement on structure and secretory function of offspring rat ventral prostate

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Santos, Sergio A. A. [1] ; Rinaldi, Jaqueline C. [1] ; Martins, Amanda E. [1] ; Camargo, Ana C. L. [1] ; Leonelli, Carina [1] ; Delella, Flavia K. [1] ; Felisbino, Sergio L. [1] ; Justulin, Jr., Luis A. [1]
Total Authors: 8
[1] Univ Estadual Paulista, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: General and Comparative Endocrinology; v. 206, p. 60-71, SEP 15 2014.
Web of Science Citations: 7

Clinical and experimental studies have shown that exposure to adverse conditions during the critical stages of embryonic, fetal or neonatal development lead to a significantly increased risk of later disease. Diabetes during pregnancy has been linked to increased risk of obesity and diabetes in offspring. Here, we investigated whether mild gestational diabetes mellitus (GDM) followed or not by maternal insulin replacement affects the ventral prostate (VP) structure and function in male offspring at puberty and adulthood. Pregnant rats were divided into the following 3 groups: control (CT); streptozotocin (STZ)-induced diabetes (D); and D plus insulin replacement during lactation (GDI). The male offspring from different groups were euthanized at postnatal day (PND) 60 and 120. Biometrical parameters, hormonal levels and prostates were evaluated. Mild-GDM promoted reduction in the glandular parenchyma and increased collagen deposition. Insulin replacement during lactation restored the VP morphology. Most importantly, mild-GDM decreased the androgen-induced secretory function as determined by prostatein expression, and insulin replacement reversed this effect. Our results demonstrated that mild GDM impairs VP parenchyma maturation, which is associated with an increase in the fibromuscular stroma compartment. Functionally, the reduction in the VP parenchyma decreases the glandular secretory activity as demonstrated by low expression of prostatein, a potent immunosuppressor factor that protects sperm from immunologic damage into the feminine reproductive tract. This change could lead to impairment of reproductive function in male offspring from diabetic mothers. Maternal insulin replacement during the weaning period apparently restores the prostate function in male offspring. (C) 2014 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/18100-9 - Effect of gestational diabetes on rat ventral prostate: morphological analysis, cellular proliferation and apoptosis and expression of androgen receptor and prostatein
Grantee:Luis Antonio Justulin Junior
Support type: Regular Research Grants
FAPESP's process: 11/16522-0 - Effects of gestational diabetes on Wistar rat ventral prostate: morphometrical analysis, cellular proliferation and death and expression of androgen receptor and prostatein
Grantee:Sérgio Alexandre Alcantara dos Santos
Support type: Scholarships in Brazil - Master