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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

UCP1 and UCP3 Expression Is Associated with Lipid and Carbohydrate Oxidation and Body Composition

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Author(s):
Oliveira, Bruno A. P. [1] ; Pinhel, Marcela A. S. [1] ; Nicoletti, Carolina F. [1] ; Oliveira, Cristiana C. [1] ; Quinhoneiro, Driele C. G. [1] ; Noronha, Natalia Y. [1] ; Marchini, Julio S. [1] ; Marchry, Ana J. [1] ; Junior, Wilson S. [2] ; Nonino, Carla B. [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Dept Internal Med, Ribeirao Preto Med Sch, BR-14049 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Surg & Anat, Ribeirao Preto Med Sch, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 11, n. 3 MAR 9 2016.
Web of Science Citations: 7
Abstract

Background/Objective Uncoupling proteins (UCPs) are located in the inner membrane of mitochondria. These proteins participate in thermogenesis and energy expenditure. This study aimed to evaluate how UCP1 and UCP3 expression influences substrate oxidation and elicits possible changes in body composition in patients submitted to bariatric surgery. Subjects/Methods This is a longitudinal study comprising 13 women with obesity grade III that underwent bariatric surgery and 10 healthy weight individuals (control group). Body composition was assessed by bioelectrical impedance. Carbohydrate and fat oxidation was determined by indirect calorimetry. Subcutaneous adipose tissue was collected for gene expression analysis. QPCR was used to evaluate UCP1 and UCP3 expression. Results Obese patients and the control group differed significantly in terms of lipid and carbohydrate oxidation. Six months after bariatric surgery, the differences disappeared. Lipid oxidation correlated with the percentage of fat mass in the postoperative period. Multiple linear regression analysis showed that the UCP1 and UCP3 genes contributed to lipid and carbohydrate oxidation. Additionally, UCP3 expression was associated with BMI, percentage of lean body mass, and percentage of mass in the postoperative period. Conclusions UCP1 and UCP3 expression is associated with lipid and carbohydrate oxidation in patients submitted to bariatric surgery. In addition, UCP3 participates in body composition modulation six months postoperatively. (AU)

FAPESP's process: 13/08916-4 - Analysis of the expression of genes related to energy expenditure and lipid metabolism in individuals with grade III obesity before and after interventions for weight loss
Grantee:Carla Barbosa Nonino
Support Opportunities: Regular Research Grants
FAPESP's process: 13/06563-7 - Analysis of the expression of genes related to energy expenditure of grade III obese before and after bariatric surgery
Grantee:Bruno Affonso Parenti de Oliveira
Support Opportunities: Scholarships in Brazil - Master