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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Male fertility potential alteration in rheumatic diseases: a systematic review

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Author(s):
Tiseo, Bruno Camargo [1] ; Cocuzza, Marcello [1] ; Bonfa, Eloisa [2] ; Srougi, Miguel [1] ; Silva, Clovis A. [2, 3]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Med, Dept Urol, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Div Reumatol, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Unidade Reumatol Pediat, Dept Pediat, BR-05508 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: INTERNATIONAL BRAZ J UROL; v. 42, n. 1, p. 11-21, JAN-FEB 2016.
Web of Science Citations: 10
Abstract

ABSTRACT Background Improved targeted therapies for rheumatic diseases were developed recently resulting in a better prognosis for affected patients. Nowadays, patients are living longer and with improved quality of life, including fertility potential. These patients are affected by impaired reproductive function and the causes are often multifactorial related to particularities of each disease. This review highlights how rheumatic diseases and their management affect testicular function and male fertility. Materials and Methods A systematic review of literature of all published data after 1970 was conducted. Data was collected about fertility abnormalities in male patients with systemic lupus erythematosus, rheumatoid arthritis, dermatomyositis, ankylosing spondylitis, Behçet disease and gout. Two independent researchers carried out the search in online databases. Results A total of 19 articles were included addressing the following diseases: 7 systemic lupus erythematosus, 6 Behçet disease, 4 ankylosing spondylitis, 2 rheumatoid arthritis, 2 dermatomyositis and one gout. Systemic lupus erythematosus clearly affects gonadal function impairing spermatogenesis mainly due to antisperm antibodies and cyclophosphamide therapy. Behçet disease, gout and ankylosing spondylitis patients, including those under anti-TNF therapy in the latter disease, do not seem to have reduced fertility whereas in dermatomyositis, the fertility potential is hampered by disease activity and by alkylating agents. Data regarding rheumatoid arthritis is scarce, gonadal dysfunction observed as consequence of disease activity and antisperm antibodies. Conclusions Reduced fertility potential is not uncommon. Its frequency and severity vary among the different rheumatic diseases. Permanent infertility is rare and often associated with alkylating agent therapy. (AU)

FAPESP's process: 14/14806-0 - Evaluation of ovarian reserve, antibody anti-corpus luteum, cervicovaginal cytology, lower genital tract infections, metabolomics and ovulatory dysfunction in women with juvenile idiopathic arthritis
Grantee:Clovis Artur Almeida da Silva
Support Opportunities: Regular Research Grants