Physical and Chemical Properties and Subcutaneous Implantation of Mineral Trioxide Aggregate Mixed with Propylene Glycol

Author(s)

Marciano, Marina Angelica ^[1] ; Guimaraes, Bruno Martini ^[1] ; Amoroso-Silva, Pablo ^[1] ; Camilleri, Josette ^[2] ; Hungaro Duarte, Marco Antonio ^[1]

Affiliation

^[1] Univ Sao Paulo, Dent Sch Bauru, Dept Dent, BR-09500900 Sao Paulo - Brazil

^[2] Univ Malta, Fac Dent Surg, Dept Restorat Dent, Msida - Malta

• Document type: Journal article
• Source: JOURNAL OF ENDODONTICS; v. 42, n. 3, p. 474-479, MAR 2016.
• Web of Science Citations: 9

Abstract

Introduction: The aim of this study was to evaluate the physical, chemical, and biological properties of mineral trioxide aggregate (MTA) mixed with 80% distilled water and 20% propylene glycol (PG) compared with MTA mixed with distilled water only. Methods: Flowability, film thickness, and solubility were analyzed according to American National Standards Institute/American Dental Association specification 57/2000. Initial and final setting times were assessed according to American Society for Testing and Materials specification C266/08. Porosity was assessed by using mercury intrusion porosimetry after 1 and 28 days of hydration, and the pH and calcium ion release were assessed after 3, 24, 72, and 168 hours. For the tissue reaction, the cements were implanted in 24 albino rats (2 groups, n = 12). An analysis of the inflammatory infiltrate was performed after 15, 30, and 60 days. Results: MTA + PG exhibited lower film thickness and higher final setting time. No differences were verified for flowability (P > .05). MTA PG showed high porosity at 1 day of hydration (P < .05). All the test cements demonstrated an alkaline pH. Microscopic analysis of the specimens revealed neoformation of connective tissue in contact with the cements. Conclusions: The introduction of PG as a mixing vehicle alters the physical and chemical properties of MTA and is biologically acceptable. (AU)

• FAPESP's process: 13/04054-8 - Analysis of the dental discoloration with MTA and Portland cement using a bovine dental model
• Grantee: Marina Angélica Marciano da Silva
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 14/01003-6 - Aluminum chloride and aluminum fluoride added to MTA Angelus to inhibit the dental discolouration: evaluation of physical, chemical and biological properties
• Grantee: Marina Angélica Marciano da Silva
• Support Opportunities: Scholarships in Brazil - Post-Doctoral