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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Deletion and low expression of NFKBIA are associated with poor prognosis in lower-grade glioma patients

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Author(s):
Kinker, Gabriela Sarti [1] ; Thomas, Andrew Maltez [2, 3, 4] ; Carvalho, Vinicius Jardim [3, 5] ; Lima, Felipe Prata [2, 3, 6] ; Fujita, Andre [7]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Physiol, Inst Biosci, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil
[3] Univ Sao Paulo, Bioinformat Grad Program, Sao Paulo - Brazil
[4] AC Camargo Canc Ctr, Int Res Ctr, Med Genom Lab, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biosci, Dept Bot, Sao Paulo - Brazil
[6] Fed Inst Alagoas, Alagoas - Brazil
[7] Univ Sao Paulo, Dept Comp Sci, Inst Math & Stat, Sao Paulo - Brazil
Total Affiliations: 7
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 6, APR 7 2016.
Web of Science Citations: 4
Abstract

Lower-grade gliomas (LGGs), which are uniformly fatal in young adults, are classified as grades II-III tumors according to their histological features. The NF kappa B transcription factor, a crucial player in cancer initiation and progression, is inactivated in the cytoplasm by inhibitory proteins (I kappa Bs) that have been shown to exert tumor-suppressor activity. Therefore, using The Cancer Genome Atlas copy number alteration and RNA-Seq data from 398 patients, we evaluated the association between the expression and dosage of NFKBIA, which encodes I kappa B alpha, and the overall malignancy of LGGs. Deletion and low expression of NFKBIA were associated with enhanced tumor aggressiveness and poor prognosis in LGGs. Accordingly, the dosage and expression of NFKBIA were independent prognostic factors for 5-year survival (dosage: P = 0.016; expression: P = 0.002) and 5-year recurrence-free survival (dosage: P = 0.009; expression: P = 0.005). Moreover, gene set enrichment analyses and co-expression network analyses indicated a role for NFKBIA in the negative regulation of cell proliferation, possibly through the modulation of downstream NF kappa B activation. Overall, the present findings reveal the prognostic value of NFKBIA in LGGs, reinforcing the relevance of NF kappa B signaling in the development and progression of gliomas. (AU)

FAPESP's process: 15/01507-7 - Microbial community profiling of human cancers
Grantee:Andrew Maltez Thomas
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/27287-0 - Characterization of the melatonergic system of human gliomas and its implication on tumor aggressiveness and invasiveness
Grantee:Gabriela Sarti Kinker
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/03447-6 - Combinatorial structures, optimization, and algorithms in theoretical Computer Science
Grantee:Carlos Eduardo Ferreira
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/09576-5 - Development of computational-statistical methods to construct, model and analyze biological networks associated with human diseases
Grantee:André Fujita
Support type: Regular Research Grants
FAPESP's process: 15/01587-0 - Storage, modeling and analysis of dynamical systems for e-Science applications
Grantee:João Eduardo Ferreira
Support type: Research Grants - eScience and Data Science Program - Thematic Grants